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Başlık: High level fluoroquinolone resistance in Escherichia coli isolated from animals in Turkey is due to multiple mechanisms
Yazarlar: Webber, Mark A.
Piddock, Laura J. V.
Uludağ Üniversitesi/Veteriner Fakültesi/Moleküler Farmakoloji Laboratuvarı.
Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0003-4337-577X
0000-0001-9018-1842
0000-0002-9212-8743
Şahintürk, Pınar
Arslan, Erdem
Büyükcangaz, Esra
Sonal, Songül
Şen, Ayşin
Ersoy, Figen
Cengiz, Murat
ABE-5935-2020
AAI-6817-2021
AAL-2323-2020
ABI-4237-2020
AAH-1820-2021
K-3299-2019
55342852700
55236738400
25649139400
7801642676
7401592869
55088196700
16635026700
Anahtar kelimeler: Veterinary sciences
Fluoroquinolone resistance
E. coli
Animals
PCR
qRT-PCR
Mediated quinolone resistance
Antibiotic-resistance
Salmonella
Prevalence
Efflux
Genes
Oqxab
Yayın Tarihi: 22-Eki-2015
Yayıncı: TÜBİTAK
Atıf: Şahintürk, P. vd. (2016). "High level fluoroquinolone resistance in Escherichia coli isolated from animals in Turkey is due to multiple mechanisms". Turkish Journal of Veterinary and Animal Sciences, 40(2), 214-218.
Özet: The aim of this study was to determine the molecular mechanisms of fluoroquinolone resistance in E. coli isolated from cattle, goats, sheep, cats, and dogs in Turkey. Twenty nonreplicate E. coli isolates (chosen on the basis of RAPD pattern) from food-producing animals were selected for the study. To identify phenotypic differences between isolates, the sum of the MIC values of 14 antimicrobials was calculated; values ranged from 565 to 2520 mu g/mL, indicating the diversity in antimicrobial resistance present in the panel of isolates. PCR and qRT-PCR were used to characterize the presence and expression levels of known molecular mechanisms of fluoroquinolone resistance. The number of E. coli isolates having single, double, and triple topoisomerase mutations was 2, 10, and 5, respectively. Moreover, the number of qnrA -, qnrS -, oqxB -, and aac(6') Ib-cr-containing E. coli isolates was 1, 4, 1, and 17, respectively. Increased expression of acrB and soxS was detected in 2 and 9 isolates, respectively. The results of this study show a wide range of different mechanisms of fluoroquinolone resistance in E. coli isolates in Turkey.
URI: https://doi.org/10.3906/vet-1506-74
https://journals.tubitak.gov.tr/veterinary/vol40/iss2/14/
http://hdl.handle.net/11452/29649
ISSN: 1300-0128
Koleksiyonlarda Görünür:Scopus
TrDizin
Web of Science

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