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Başlık: A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model
Yazarlar: Çetin, Yüksel
Adıgüzel, Zelal
Polat, Hivda Ulbeği
Akkoç, Tolga
Taş, Arzu
Çelik, Gökalp
Çarıkçı, Barış
Ulukaya, Engin
Açılan, Ceyda
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.
0000-0002-2849-3332
Yılmaz, Veysel T.
Cevatemre, Buse
L-7238-2018
AHD-2050-2022
55693788600
56441123900
Anahtar kelimeler: Oncology
Pharmacology & pharmacy
Anticancer drugs
Antitumor activity
Apoptosis
In-vitro characterization
In-vivo characterization
Palladium(II)-saccharinate complex with terpyridine
Toxicity
Cells in-vitro
Thoracic aortic-aneurysms
Liver-function tests
Platinum compounds
Saccharinate complex
Induced hepatotoxicity
Palladium complexes
Oxidative stress
Antitumor agents
Apoptosis
Yayın Tarihi: 2017
Yayıncı: Lippincott Williams & Wilkins
Atıf: Çetin, Y. vd. (2017). ''A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model''. Anti-Cancer Drugs, 28(8), 898-910.
Özet: The main aim of this study is to assess the safety and antitumor efficacy of a palladium(II) (Pd)-saccharinate complex with terpyridine. To characterize the Pd(II) complex in vitro, its cytotoxicity was evaluated using a water-soluble tetrazolium salt cell viability assay and the mechanism of cell death was assessed by DNA fragmentation/condensation and live cell imaging analyses. The antitumor efficacy and safety of the Pd(II) complex in-vivo were examined by analyzing reduction in tumor size, changes in body and organ weight, histopathological analysis of liver, kidney, and tumor sections, and biochemical analysis of serum in C57BL/6 mice. Our results showed that the Pd(II) complex was more cytotoxic to cancer cells than noncancer cell lines and caused cell death through apoptotic pathways. The treatment of the Pd(II) complex in tumor-bearing mice effectively reduced the tumor size at half the dose used for cisplatin. The Pd(II) complex appeared to exert less liver damage than the cisplatin-based complex on changes in the hepatic enzymes levels in the serum. Hence, the complex appears to be a potential chemotherapeutic drug with high antitumor efficacy and fewer hepatotoxic complications, providing an avenue for further studies.
URI: https://doi.org/10.1097/CAD.0000000000000531
https://journals.lww.com/anti-cancerdrugs/Fulltext/2017/09000/A_palladium_II__saccharinate_complex_of.9.aspx
1473-5741
http://hdl.handle.net/11452/30362
ISSN: 0959-4973
Koleksiyonlarda Görünür:Scopus
Web of Science

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