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Başlık: Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors
Yazarlar: Gokçen, Kaan
Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
0000-0002-9790-7295
0000-0002-0710-0923
Kılıçarslan, Hakan
Coşkun, Burhan
Ersoy, Alparslan
Kaygısız, Onur
Kordan, Yakup
AAM-9726-2020
L-9439-2019
AAH-9704-2021
AAH-5054-2021
56007473800
57140828400
35612977100
16637252400
9633365800
Anahtar kelimeler: Urology & nephrology
Chronic-renal-failure
Nitric-oxide
Asymmetric dimethylarginine
Endothelial dysfunction
Erythropoietin
Sexual dysfunction
Abnormalities
Hypertension
Physiology
Inhibitor
Yayın Tarihi: 2016
Yayıncı: Canadian Urological Association
Atıf: Gökçen, K. vd. (2016). "Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors". CUAJ-Canadian Urological Association Journal, 10(1-2), E41-E45.
Özet: Introduction: Hormonal, neurogenic, vasculogenic, and psychogenic impairments, as well as endothelial dysfunction may play a role in erectile dysfunction (ED) in patients with chronic kidney disease (CKD). Asymmetrical dimethylarginine (ADMA) is an inhibitor of nitric oxide, which is the key element of ED. ADMA levels are increased in CKD. We aimed to evaluate the effect of serum ADMA, prolactin, testosterone, and hemoglobin levels on erectile function of patients with CKD and control subjects. Methods: A total of 42 men with CKD and 25 age-matched controls were enrolled. The patients with CKD were categorized into group 1 and group 2 based on whether they had ED according to their response to International Index of Erectile Function questionnaire (IIEF-EFD). Group 3 was a control group. Serum ADMA, total testosterone prolactin, and hemoglobin levels of the patients were evaluated. Results: Serum ADMA, testosterone, and hemoglobin levels were similar between group 1 and 2, serum prolactin level was significantly high in group 1 than in group 2 or 3 (control group). There was no correlation between ADMA levels and IIEF-EFD scores of patients with CKD. Conclusions: The results of this study suggest serum ADMA level is not related with ED in patients with CKD. Also, low testosterone and hemoglobin levels were not significant factors. High levels of serum prolactin are related with ED in patients with CKD.
URI: https://doi.org/10.5489/cuaj.3170
https://cuaj.ca/index.php/journal/article/view/3170
http://hdl.handle.net/11452/29930
ISSN: 1911-6470
1920-1214
Koleksiyonlarda Görünür:Scopus
Web of Science

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