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Başlık: Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis
Yazarlar: Escribano, Damian
Tvarijonaviciute, Asta
Joaquin Ceron, Jose
Pardo-Marin, Luis
Torrecillas, Alejandro
Martinez-Subiela, Silvia
Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.
0000-0001-9836-0749
Kocatürk, Meriç
Yılmaz, Zeki
V-5578-2017
36437200800
35944810500
Anahtar kelimeler: Immunology
Microbiology
Veterinary sciences
Leishmaniosis
Dogs
Apolipoprotein A1
Treatment monitoring
Visceral leishmaniasis
Proteins
Identification
Proteomics
Diagnosis
Yayın Tarihi: 10-Eki-2016
Yayıncı: Elsevier
Atıf: Escribano, D. vd. (2016). "Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis". Comparative Immunology Microbiology and Infectious Diseases, 49, 82-87.
Özet: The aims of this study were: the identification of proteins differentially represented in the serum proteome of dogs with leishmaniosis after treatment and the verification of one selected protein as a possible biomarker for treatment monitoring. Serum samples from five dogs with leishmaniosis, before and after treatment were pooled into two groups and analysed using 2-dimensional electrophoresis followed by mass spectrometry analysis (MS). The MS analysis allowed the identification of 8 proteins differently expressed. APO-A1 was selected and an immunoturbidimetric assay was validated for its measurement in dogs. Significantly decreased concentrations of APO-A1 in dogs with leishmaniosis and a significant increase after a good response to the treatment were observed, suggesting that APO-A1 could be a potential biomarker of treatment monitoring with the advantages of an automated measurement.
URI: https://doi.org/10.1016/j.cimid.2016.10.002
https://www.sciencedirect.com/science/article/pii/S0147957116300984
http://hdl.handle.net/11452/29618
ISSN: 0147-9571
1878-1667
Koleksiyonlarda Görünür:Scopus
Web of Science

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