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http://hdl.handle.net/11452/29512
Başlık: | Catheter-directed ultrasound-accelerated thrombolysis may be life-saving in patients with massive pulmonary embolism after failed systemic thrombolysis |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı. 0000-0001-8404-8252 0000-0002-3425-0740 0000-0002-8974-8837 Sağ, Saim Nas, Ömer Fatih Kaderli, Aysel Aydın Özdemir, Bülent Baran, İbrahim Erdoğan, Cüneyt Güllülü, Sümeyye Hakyemez, Bahattin Aydınlar, Ali AAW-9185-2020 AAG-8561-2021 AAI-2318-2021 AAI-6632-2021 12140008100 51864050100 7801322152 7004168959 35572557400 8293835700 57204660708 6602527239 6603131517 |
Anahtar kelimeler: | Cardiovascular system & cardiology Hematology Acute pulmonary embolism Failed systemic thrombolytic treatment Catheter directed thrombolysis EkoSonic endovascular system European-society Intermediate Embolectomy Therapy Fragmentation Fibrinolysis Guidelines Management Cardiology Safety |
Yayın Tarihi: | Eki-2016 |
Yayıncı: | Springer |
Atıf: | Sağ, S. vd. (2016). "Catheter-directed ultrasound-accelerated thrombolysis may be life-saving in patients with massive pulmonary embolism after failed systemic thrombolysis". Journal of Thrombosis and Thrombolysis, 42(3), 322-328. |
Özet: | The treatment options for high risk acute pulmonary embolism (PE) patients with failed systemic thrombolytic treatment (STT) is limited. The clinical use of catheter directed thrombolysis with the EkoSonic Endovascular System (EKOS) in this population has not been evaluated before. Catheter directed thrombolysis is an effective treatment modality for high risk PE patients with failed STT. Thirteen consecutive patients with failed STT were included in the study. EKOS catheters were placed and tissue plasminogen activator (t-PA) in combination with unfractionated heparin were given. Clinical and echocardiographic properties of the patients were collected before EKOS, at the end of EKOS and during the follow-up visit 6 months after discharge. The duration of EKOS treatment was 21.8 +/- 3.8 h and the total dose of tPA was 31.2 +/- 15.3 mg. One patient who presented with cardiac arrest died and the clinical status of the remaining subjects improved significantly. Any hemorrhagic complication was not observed. EKOS resulted in significant improvement of right ventricular functions and decrease of systolic pulmonary artery pressure. During a follow-up period of 6 months none of the patients died or suffered recurrent PE. In addition, echocardiographic parameters or right ventricular function significantly got better compared to in-hospital measurements. EKOS is an effective treatment modality for high risk PE patients with failed STT and can be applied with very low hemorrhagic complications. |
URI: | https://doi.org/10.1007/s11239-016-1370-3 https://link.springer.com/article/10.1007/s11239-016-1370-3 http://hdl.handle.net/11452/29512 |
ISSN: | 0929-5305 1573-742X |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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