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http://hdl.handle.net/11452/29346
Başlık: | Colchicine in renal Medicine: New virtues of an ancient friend |
Yazarlar: | Solak, Yalçın Siriopol, Dimitrie Yılmaz, Mahmut İlker Ortiz, Alberto Covic, Adrian Kanbay, Mehmet Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Anabilim Dalı. Yıldız, Abdulmecit 56256977500 |
Anahtar kelimeler: | Hematology Urology & nephrology Colchicine Fibrosis Inflammation Kidney disease Familial mediterranean fever Chronic cyclosporine nephrotoxicity Inflammatory cell infiltration Primary systemic amyloidosis Primary biliary-cirrhosis Chronic kidney-disease Diabetic-nephropathy Molecular-mechanisms Iinduced neuromyopathy Interstitial fibrosis |
Yayın Tarihi: | 18-Kas-2016 |
Yayıncı: | Karger |
Atıf: | Solak, Y. vd. (2017). ''Colchicine in renal Medicine: New virtues of an ancient friend''. Blood Purification, 43(1-3), 125-135. |
Özet: | Colchicine is a plant-derived alkaloid that disrupts the cell microtubule system and accumulates in neutrophils, inhibiting neutrophil adhesion and recruitment. Colchicine has been used extensively in the prevention and treatment of gouty arthritis attacks, familial Mediterranean fever attacks and resultant AA amyloidosis, and recurrent pericarditis. Colchicine also disrupts the intracellular traffic of additional inflammatory and fibrosis mediators. Renal fibrosis is the final common pathway of chronic renal disease. Colchicine had anti-fibrotic effects in experimental diabetic nephropathy, renal mass reduction, and cyclosporine nephrotoxicity among others and is undergoing clinical trials for non-diabetic metabolic syndrome and diabetic nephropathy. In this review, we summarize the anti-inflammatory and anti-fibrotic properties of colchicine in experimental and clinical studies in renal diseases or other fibrotic disease processes with renal consequences. We also discuss the potential future uses of colchicine in renal medicine and challenges faced with its use in patients with impaired kidney function. |
URI: | https://doi.org/10.1159/000454669 https://www.karger.com/Article/FullText/454669 http://hdl.handle.net/11452/29346 |
ISSN: | 0253-5068 1421-9735 |
Koleksiyonlarda Görünür: | Web of Science |
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