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Başlık: Effects of capsaicin on testis ghrelin expression in mice
Yazarlar: Uludağ Üniversitesi/Veterinerlik Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.
İlhan, Tuncay
Erdost, Hatice
AAH-9216-2021
AAH-8859-2021
16549312600
6505787570
Anahtar kelimeler: Biotechnology & applied microbiology
Cell biology
Capsaicin
Ghrelin
Mice
Testis
Testosterone
Red hot pepper
Acylated peptide
Histological investigations
Growth
Capsicum
Receptor
Diet
Organs
Mouse
Rats
Animalia
Capsicum frutescens
Mus
Yayın Tarihi: Oca-2013
Yayıncı: Taylor & Francis
Atıf: İlhan, T. ve Erdost, H. (2013). "Effects of capsaicin on testis ghrelin expression in mice". Biotechnic and Histochemistry, 88(1), 10-18.
Özet: Capsaicin (CAP), the active substance of red hot peppers, has been reported to stimulate development of the gonad. Ghrelin is an acylated polypeptide hormone that is secreted predominantly by endocrine cells of the stomach. There is evidence that ghrelin is involved in reproductive function. Ghrelin significantly inhibits testosterone secretion in a dose-dependent manner. We investigated the effect of CAP on ghrelin expression in testes of mice and on testosterone levels during pubertal and adult periods. We used a variety of morphometric, immunohistochemical and biochemical methods, and western blot analysis. The animals were divided into two age groups: puberty and adult. Control groups for both age groups were fed with standard diet and experimental groups were fed with a diet containing 0.02% CAP. Testes were collected quickly after sacrifice. After dehydration, the specimens were embedded in paraffin and 5 mu m sections were cut, and Crossman's triple staining and immunohistochemical staining for ghrelin were applied. Immunohistochemical staining with ghrelin antibody for both age groups demonstrated immunoreaction especially in Leydig and Sertoli cells, but no reaction was observed in spermatogenic cells. Ghrelin immunoreaction was less intense in the experimental groups. Serum testosterone levels were increased in both experimental groups, especially in adults. More spermatocytes were observed in the experimental group compared to the control group. In both pubertal and adult experimental groups, the seminiferous epithelium was thick. CAP appears to enhance testicular cell proliferation and can affect the release of ghrelin and testosterone directly or indirectly.
URI: https://doi.org/10.3109/10520295.2012.724083
https://www.tandfonline.com/doi/full/10.3109/10520295.2012.724083
http://hdl.handle.net/11452/29109
ISSN: 1052-0295
1473-7760
Koleksiyonlarda Görünür:Scopus
Web of Science

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