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Başlık: Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
0000-0003-0863-1547
Kahveci, Nevzat
Güleç, Güldal Süyen
Büyükcoşkun, Naciye İşbil
AAG-7070-2021
AAH-1692-2021
C-5730-2015
6602752303
55665951400
6602597846
Anahtar kelimeler: Neurosciences & neurology
Yayın Tarihi: Haz-2010
Yayıncı: Wiley
Atıf: Kahveci, N. vd. (2010). "Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat". Epilepsia, 51(Supplement 4), Special Issue, 84-84.
Özet: Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat. Rats were pretreated with GLP-1 (1-1000ng/5μl; i.c.v.) or saline (5μl; i.c.v.) 30min before seizure induction by pilocarpine (2.4mg/5μl; i.c.v.) and with GLP-1 (1, 10, 100ng/5μl; i.c.v.) or saline (5μl; i.c.v.) 30min before the open field test or the elevated plus maze test. GLP-1 did not produce any protective effect against pilocarpine-induced seizures and did not also produce statistically significant differences in the number of squares visited (measure of locomotor activity) or number of rearings (measure of exploratory behaviour), compared to the saline-treated rats in the open field test. On the other hand, GLP-1 (1ng and 10ng; i.c.v.) induced an anxiogenic effect, indicated by a decrease in the time spent in open arms, an increase in the time spent in closed arms, and a decrease in the anxiety scores in the elevated plus maze test. Pretreatment with an arginine vasopressin (AVP) V1 receptor antagonist (125ng/5μl; i.c.v.) and L-NAME (100μg/5μl and 200μg/5μl) significantly abolished the anxiogenic effect of GLP-1 (1ng/5μl; i.c.v.). These results suggest that, centrally-injected GLP-1 produces anxiogenic effects via NO pathway and AVP V1 receptors, but does not have any effects on pilocarpine-induced seizures or locomotor and exploratory activity in the open field test.
Açıklama: Bu çalışma, 27 Haziran-01 Temmuz 2010 tarihleri arasında Montreal[Kanada]’da düzenlenen 9. European Congress on Epileptology’da bildiri olarak sunulmuştur.
URI: https://doi.org/10.1016/j.npep.2010.02.002
https://www.sciencedirect.com/science/article/pii/S0143417910000260
http://hdl.handle.net/11452/28679
ISSN: 0013-9580
Koleksiyonlarda Görünür:Scopus
Web of Science

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