Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28322
Title: Gallstone disease does not predict liver histology in nonalcoholic fatty liver disease
Authors: Yılmaz, Yusuf
Akın, Hakan Levent
Çolak, Yaşar
Öztürk, Oğuzhan
Şenateş, Ebubekir
Tuncer, İlyas
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
0000-0001-8944-2793
Ayyıldız, Talat
Dolar, Enver
AAG-9177-2021
6603155277
6602075084
Keywords: Gallstone disease
Non-alcoholic fatty liver disease
Nonalcoholic steatohepatitis
Fibrosis
Metabolic syndrome
Gallbladder-disease
Insulin-resistance
Risk-factors
Steatohepatitis
Progression
Prevalence
Gastroenterology & hepatology
Issue Date: May-2014
Publisher: Editorial Office Gut & Liver
Citation: Yılmaz, Y. vd. (2014). "Gallstone disease does not predict liver histology in nonalcoholic fatty liver disease". Gut and Liver, 8(3), 313-317.
Abstract: Background/Aims: We sought to examine whether the presence of gallstone disease (GD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) is associated with liver fibrosis and histological nonalcoholic steatohepatitis (NASH) score. Methods: We included 441 Turkish patients with biopsy-proven NAFLD. GD was diagnosed in the presence of sonographic evidence of gallstones, echogenic material within the gallbladder with constant shadowing and little or no visualization of the gallbladder or absence of gallbladder at ultrasonography, coupled with a history of cholecystectomy. Results: Fifty-four patients (12.2%) had GD (GD+ subjects). Compared with the GD- subjects, GD+ patients were older, had a higher body mass index and were more likely to be female and have metabolic syndrome. However, GD+ patients did not have a higher risk of advanced fibrosis or definite NASH on histology. After adjustment for potential confounding variables, the prevalence of GD in NAFLD patients was not associated with significant fibrosis (>= 2) (odds ratio [OR], 1.06; 95% confidence interval [Cl], 0.53 to 2.21; p=0.68) or definite NASH (OR, 1.03; 95% Cl, 0.495 to 2.12; p=0.84). Conclusions: The presence of GD is not independently associated with advanced fibrosis and definite NASH in adult Turkish patients with biopsy-proven NAFLD.
URI: https://doi.org/10.5009/gnl.2014.8.3.313
https://www.gutnliver.org/journal/view.html?volume=8&number=3&spage=313&year=2014
http://hdl.handle.net/11452/28322
ISSN: 1976-2283
2005-1212
Appears in Collections:Scopus
Web of Science

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