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http://hdl.handle.net/11452/28267
Başlık: | Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro |
Yazarlar: | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı. 0000-0003-1620-1918 0000-0002-3595-6286 0000-0002-7687-3284 Cinkılıç, Nilüfer Tüzün, Ece Çetintaş, Sibel Kahraman Vatan, Özgür Yılmaz, Dilek Çavaş, Tolga Tunç, Sema Özkan, Lütfi Bilaloğlu, Rahmi AAH-3508-2021 AAH-5296-2021 AAA-7047-2020 O-7508-2015 26533892300 55150260600 6505881756 16235098100 6701369462 6602989548 55557323500 55915679400 6505804122 |
Anahtar kelimeler: | Radioprotection Cinnamic acid X-ray radiation Micronuclei Alkaline comet assay Genomic instability Induced DNA-damage Gamma-radiation Lipid-peroxidation Chromosomal damage Antioxidants Derivatives Assay Micronuclei Flavonoids Generation Biotechnology & applied microbiology Genetics & heredity Toxicology |
Yayın Tarihi: | Ağu-2014 |
Yayıncı: | Elsevier |
Atıf: | Cinkılıç, N. vd. (2014). "Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro". Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 770, 72-79. |
Özet: | The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline comet assay, with human blood lymphocytes isolated from two healthy donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for the irradiation with 1 or 2 Gy. Treatment of the lymphocytes with cinnamic acid prior to irradiation reduced the number of micronuclei when compared with that in control samples. Treatment with cinnamic acid without irradiation did not increase the number of micronuclei and did not show a cytostatic effect in the lymphocytes. The results of the alkaline comet assay revealed that cinnamic acid reduces the DNA damage induced by X-rays, showing a significant radio-protective effect. Cinnamic acid decreased the frequency of irradiation-induced micronuclei by 16-55% and reduced DNA breakage by 17-50%, as determined by the alkaline comet assay. Cinnamic acid may thus act as a radio-protective compound, and future studies may focus on elucidating the mechanism by which cinnamic acid offers radioprotection. |
URI: | https://doi.org/10.1016/j.mrgentox.2014.04.025 https://www.sciencedirect.com/science/article/pii/S1383571814001594 http://hdl.handle.net/11452/28267 |
ISSN: | 1383-5718 1879-3592 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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