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http://hdl.handle.net/11452/27789| Title: | Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators |
| Authors: | Bridoux, Alexandre Cui, Huadong Dyskin, Evgeny Schmitzer, Andreea Ruxandra Mousa, Shaker A. Uludağ Üniversitesi/Veterinerlik Fakültesi/Temel Bilimler Bölümü. 0000-0002-5600-8162 Yalçın, Murat AAG-6956-2021 57192959734 |
| Keywords: | Thyroxine Esterification Silylation UV-vis Angiogenesis Nanopharmaceutical technology Extracelluler segment Crystal-structure Thyhroid-hormone Force-field Proteins Pharmacology & pharmacy Chemistry |
| Issue Date: | 1-Jun-2010 |
| Publisher: | Pergamon-Elsevier Science |
| Citation: | Bridoux, A. vd. (2010). "Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 20(11), 3394-3398. |
| Abstract: | Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor. |
| URI: | https://doi.org/10.1016/j.bmcl.2010.04.011 https://www.sciencedirect.com/science/article/pii/S0960894X10004713 http://hdl.handle.net/11452/27789 |
| ISSN: | 0960-894X 1464-3405 |
| Appears in Collections: | Scopus Web of Science |
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