Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/27007
Başlık: Activation-induced cytidine deaminase expression in human b cell precursors ıs essential for central b cell tolerance
Yazarlar: Cantaert, Tineke
Schickel, Jean Nicolas
Bannock, Jason M.
Ng, Yen Shing
Massad, Christopher
Oe, Tyler
Wu, Renee
Lavoie, Aubert
Walter, Jolan E.
Notarangelo, Luigi D.
Herz, Waleed Al
Ochs, Hans D.
Nonoyama, Shigeaki
Durandy, Anne
Meffre, Eric
Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
AAH-1658-2021
Kılıç, Sara Şebnem
0000-0001-8571-2581
34975059200
Anahtar kelimeler: Class-switch recombination
Somatic hypermutation
V(d)j recombination
Aıid expression
Deficiency
Mechanisms
Bcl6
P53
Translocations
Receptors
Immunology
Yayın Tarihi: 17-Kas-2015
Yayıncı: Cell Press
Atıf: Cantaert, T. vd. (2015). "Activation-induced cytidine deaminase expression in human b cell precursors is essential for central b cell tolerance". Immunity, 43(5), 884-895.
Özet: Activation-induced cytidine deaminase (AID), the enzyme- mediating class-switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes, is essential for the removal of developing autoreactive B cells. How AID mediates central B cell tolerance remains unknown. We report that AID enzymes were produced in a discrete population of immature B cells that expressed recombination-activating gene 2 (RAG2), suggesting that they undergo secondary recombination to edit autoreactive antibodies. However, most AID(+) immature B cells lacked anti-apoptotic MCL-1 and were deleted by apoptosis. AID inhibition using lentiviral-encoded short hairpin (sh)RNA in B cells developing in humanized mice resulted in a failure to remove autoreactive clones. Hence, B cell intrinsic AID expression mediates central B cell tolerance potentially through its RAG-coupled genotoxic activity in self-reactive immature B cells.
URI: https://doi.org/10.1016/j.immuni.2015.10.002
https://www.sciencedirect.com/science/article/pii/S1074761315004021
http://hdl.handle.net/11452/27007
ISSN: 1074-7613
Koleksiyonlarda Görünür:Scopus
Web of Science

Bu öğenin dosyaları:
Dosya Açıklama BoyutBiçim 
Kılıç_vd_2015.pdf3.96 MBAdobe PDFKüçük resim
Göster/Aç


Bu öğe kapsamında lisanslı Creative Commons License Creative Commons