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Title: | In vitro genotoxicity evaluation of acetamiprid in CaCo-2 cells using the micronucleus, comet and gamma H2AX foci assays |
Authors: | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. 0000-0002-7687-3284 0000-0002-3595-6286 Çavaş, Tolga Cinkılıç, Nilufer Vatan, Özgür Yılmaz, Dilek Coşkun, Mümün AAH-3508-2021 O-7508-2015 AAH-5296-2021 6602989548 26533892300 16235098100 6701369462 57204274361 |
Keywords: | Biochemistry & Molecular Biology Entomology Physiology Acetamiprid Genotoxic CaCo-2 Comet Micronucleus Gamma H2AX Dna-damage Neonicotinoid insecticides Human-lymphocytes Cytotoxicity Induction Pesticides Toxicology Relevance Apoptosis Toxicity Hexapoda |
Issue Date: | Nov-2012 |
Publisher: | Academic Press Inc Elsevier Science |
Citation: | Çavaş, T. vd. (2012). "In vitro genotoxicity evaluation of acetamiprid in CaCo-2 cells using the micronucleus, comet and gamma H2AX foci assays". Pesticide Biochemistry and Physiology, 104(3), 212-217. |
Abstract: | Acetamiprid is a member of the neonicotinoid group of insecticides commonly used against wide range of insect pests. In the present study, in vitro cytotoxicity and genotoxicity of technical grade acetamiprid was evaluated on the human intestinal CaCo-2 cells. Cytotoxicity was evaluated using the clonogenic survival and the results indicated that acetamiprid was cytotoxic on CaCo-2 cells. The cells were than treated with acetamiprid concentrations exhibit greater than 75% clonogenic survival for 24 h, to assess genotoxicity using the micronucleus, comet and gamma H2AX foci formation assays. Our results indicate that, under the experimental conditions used, acetamiprid has cytotoxic and genotoxic potential on human intestinal cells. |
URI: | https://doi.org/10.1016/j.pestbp.2012.08.004 https://www.infona.pl/resource/bwmeta1.element.elsevier-07bcadee-7020-37f8-a8e2-45f0630a01cf https://www.sciencedirect.com/science/article/pii/S0048357512001320 http://hdl.handle.net/11452/25401 |
ISSN: | 0048-3575 1095-9939 |
Appears in Collections: | Scopus Web of Science |
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