Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/25373
Başlık: Can the outcome of autoaugmentation omentocystoplasty be improved? Urodynamic, histological, and collagen content evaluation in sheep model
Yazarlar: Burgu, Berk
Keskin, Selçuk
Orhan, Diclehan
Özgencil, Eser
Şenel, Oytun
Aydoğdu, Özgü
Tekgül, Serdar
Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.
Doğan, Hasan Serkan
ABH-5513-2020
7005856022
Anahtar kelimeler: Urology & nephrology
Autoaugmentation
Collagen
Intavesical balloon
Sheep
Vascularization
Bladder autoaugmentation
Augmentation
Gastrocystoplasty
Urothelium
Yayın Tarihi: 2011
Yayıncı: Wiley
Atıf: Burgu, B. vd. (2011). "Can the outcome of autoaugmentation omentocystoplasty be improved? Urodynamic, histological, and collagen content evaluation in sheep model". Neurourology and Urodynamics, 30(7), 1371-1375.
Özet: Aim: To compare histological and urodynamic outcome of the classical detrusorotomy with and without the aid of intravesical balloon distension. We also describe a new technique with multiple detrusor incisions instead of detrusorotomy. Methods: A total of 24 animals were included in the study. Three different techniques of autoaugmentation cystoplasty were applied to surgically reduced bladders of 14 sheep. Five sheep underwent surgical reduction of bladder capacity as control group and five sheep underwent sham operation. In Group DIB (detrusor incision with balloon), standard whole thickness incisions on bladder wall were performed and a silicon balloon was inflated intravesically postoperatively. Group DMB (detrusorotomy with balloon) and Group DM (detrusorotomy) underwent standard detrusorotomy. After measuring capacities and compliances, animals were sacrificed on 90th postoperative day. Bladders were histopathologically evaluated. Expression of vascular endothelial growth factor (VEGF), CD31, and microvessel density (MVD) was noted. Quantification of collagen subtypes was also performed. Results: The mean capacity and compliance for Group DM and control were not significantly different and both were lower than other augmentation groups and sham. In Groups DMB and DM fibrosis was significantly increased. The VEGF expression was lower in Group DIB with respect to other augmentation groups whereas MVD was not significantly different. Measurement of total collagen and collagen subtypes revealed an increase in total collagen of groups DMB and DM when compared to other groups. Quantification of collagen subtypes demonstrated that types I and III were significantly increased in aforementioned groups. Conclusion: Autoaugmentation omentocystoplasty in sheep model does not result in a reliable increase in bladder capacity and compliance. Intravesical balloon inflation makes the achievement more pronounced and significantly increases the bladder capacity and compliance.
URI: https://doi.org/10.1002/nau.21010
https://onlinelibrary.wiley.com/doi/full/10.1002/nau.21010
http://hdl.handle.net/11452/25373
ISSN: 0733-2467
1520-6777
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

Bu öğenin dosyaları:
Bu öğeyle ilişkili dosya bulunmamaktadır.


DSpace'deki bütün öğeler, aksi belirtilmedikçe, tüm hakları saklı tutulmak şartıyla telif hakkı ile korunmaktadır.