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Başlık: Plasma prohepcidin levels in patients with chronic viral hepatitis: Relationship with liver fibrosis
Yazarlar: Yılmaz, Yusuf
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
Ölmez, Ömer Fatih
Gürel, Selim
26435400000
7003706434
Anahtar kelimeler: Chronic hepatitis B
Chronic hepatitis C
Histopathology
Iron
Prohepcidin
Iron stores
Expression
Infection
Gastroenterology & hepatology
Yayın Tarihi: Nis-2010
Yayıncı: Lippincott Williams & Wilkins
Atıf: Ölmez, Ö. F. vd. (2010). "Plasma prohepcidin levels in patients with chronic viral hepatitis: Relationship with liver fibrosis". European Journal of Gastroenterology and Hepatology, 22(4), 461-465.
Özet: Objectives Iron is deemed to play a crucial role in the pathophysiology of liver damage in patients with chronic viral hepatitis. Hepcidin has recently emerged as the key hormone in the regulation of iron balance and recycling. We assessed plasma prohepcidin levels in patients with chronic viral hepatitis and investigated the association of this molecule with iron parameters, histologic activity index, and liver fibrosis scores. Methods We enrolled 35 patients with chronic hepatitis C, 27 with chronic hepatitis B, and 21 healthy controls. Plasma levels of prohepcidin were measured by enzyme-linked immunosorbent assay. Results Mean prohepcidin levels were significantly lower in patients with chronic hepatitis B than in those with chronic hepatitis C (P < 0.001) and healthy comparison controls (P < 0.05). In patients with chronic hepatitis C, prohepcidin was independently associated with liver fibrosis scores (beta = -0.009, standard error = 0.003, P < 0.05). No association of prohepcidin with iron parameters was found. Conclusion Significantly lower prohepcidin levels are frequently found in patients with chronic hepatitis B. Levels of this molecule may represent a biochemical correlate of fibrosis in chronic hepatitis C virus infection.
URI: https://doi.org/10.1097/MEG.0b013e3283344708
https://pubmed.ncbi.nlm.nih.gov/19940783/
http://hdl.handle.net/11452/25370
ISSN: 0954-691X
1473-5687
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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