Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız:
http://hdl.handle.net/11452/24992
Başlık: | Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı. Çavun, Sinan Savcı, Vahide Ulus, İsmail Hakkı AAC-9702-2019 D-5340-2015 6507468595 6603687024 7004271086 |
Anahtar kelimeler: | Pharmacology and pharmacy CDP-choline Choline Cytidine Nicotinic receptor Precursor Vasopressin Rat supraoptic nucleus Conscious rats Acetylcholine-receptors Release Neurons Hypothalamus Involvement Hippocampal Hemorrhage Citicoline |
Yayın Tarihi: | Şub-2004 |
Yayıncı: | Wiley |
Atıf: | Çavun, S. vd. (2004). “Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation”. Fundamental and Clinical Pharmacology, 18(1), 71-77. |
Özet: | In the present study, both the effects of intracerebroventricular (i.c.v.) injection of cytidine-5′-diphosphate choline (CDP-choline) on plasma vasopressin levels and the choline involvement of these effects were investigated. I.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 μmol) increased plasma vasopressin levels dose- and time-dependently. I.c.v. injection of equimolar dose of choline (1 μmol) produced similar vasopressin response. However equimolar dose of cytidine (1 μmol; i.c.v.), the other hydrolysis product of CDP-choline, did not affect plasma vasopressin levels. Pretreatment of rats with hemicholinium-3, neuronal high affinity choline uptake inhibitor (20 μg; i.c.v.) blocked the vasopressin response to i.c.v. CDP-choline (1 μmol). Pretreatment of rats with mecamylamine (50 μg; i.c.v.), a nonselective nicotinic receptor antagonist, abolished the increase in plasma vasopressin induced by CDP-choline while atropine (10 μg; i.c.v.), nonselective muscarinic receptor antagonist, failed to change the response. In conclusion, intracerebroventricularly injected CDP-choline can increase plasma vasopressin levels by activating central nicotinic cholinergic receptors through the activation of presynaptic cholinergic mechanisms. |
URI: | https://doi.org/10.1046/j.0767-3981.2003.00213.x https://onlinelibrary.wiley.com/doi/10.1046/j.0767-3981.2003.00213.x http://hdl.handle.net/11452/24992 |
ISSN: | 0767-3981 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
Bu öğenin dosyaları:
Bu öğeyle ilişkili dosya bulunmamaktadır.
DSpace'deki bütün öğeler, aksi belirtilmedikçe, tüm hakları saklı tutulmak şartıyla telif hakkı ile korunmaktadır.