Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/24575
Başlık: The similarity between aspirin treatment and the lack of response to epinephrine and the frequency of aspirin resistance in healthy males
Yazarlar: Sağdilek, Engin
Korkmaz, Ahmet
Öter, Şükrü
Avcu, Ferit
Topal, Turgut
Özler, Mehmet
Uysal, Bülent
Nevruz, Oral
Beyan, Cengiz
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Özlük, Kasım
6602676331
Anahtar kelimeler: Hematology
Cardiovascular system & cardiology
Platelets
Optical aggregometer
Epinephrine
Aspirin resistance
Platelet-function
In-vitro
Responsiveness
Prevalence
Disease
Drugs
Yayın Tarihi: Nis-2011
Yayıncı: Sage Publications
Atıf: Sağdilek, E. vd. (2011). "The similarity between aspirin treatment and the lack of response to epinephrine and the frequency of aspirin resistance in healthy males". Clinical and Applied Thrombosis-Hemostasis, 17(2), 202-207.
Özet: Objectives: The lack of response of platelets against epinephrine has been discovered with a frequency of 14% to 40% in previous studies. There are studies that have demonstrated the effect of aspirin on platelets may resemble the lack of response to epinephrine. In this study, the extent of the effects of aspirin treatment on aggregation and secretion in healthy males with a lack of response to epinephrine and the frequency of aspirin resistance were investigated. Methods: Blood samples were collected at the beginning and at the end of a 10-day aspirin usage in 52 healthy males. Epinephrine, adenosine diphosphate (ADP), collagen, arachidonic acid (AA) and thrombin aggregations, and adenosine triphosphate (ATP) secretion were studied. Participants were assigned to nonresponder (< 20%), semiresponder (20%-60%), and responder (> 60%) groups, depending on their maximum aggregation responses to epinephrine. Participants who displayed an aggregation to AA at the end of the aspirin treatment were accepted to be aspirin resistant. Results: Of the 52 participants, 4 were found to be nonresponders and 3 of 52 of the participants were found to be semiresponders. Although the lack of response to epinephrine and aspirin treatment displayed similarities in aggregations using epinephrine, ADP, collagen, and thrombin, they differed in aggregations using AA and for ATP secretion. The ratio of aspirin resistance was determined to be 4:52. Conclusions: The observation of AA aggregation in the participants with a lack of response to epinephrine demonstrates that epinephrine nonresponse cannot substitute aspirin treatment. The fact that aspirin resistance is observed in healthy males supports the view that aspirin resistance exists even before the first usage.
Açıklama: Bu çalışma, 05-07 Mayıs 2006 tarihleri arasında İzmir[Türkiye]’da düzenlenen 6. National Congress of Thrombosis, Haemostasis and Angiology’da bildiri olarak sunulmuştur.
URI: https://doi.org/10.1177/1076029609356425
https://pubmed.ncbi.nlm.nih.gov/20460337/
http://hdl.handle.net/11452/24575
ISSN: 1076-0296
Koleksiyonlarda Görünür:Scopus
Web of Science

Bu öğenin dosyaları:
Dosya Açıklama BoyutBiçim 
Özlük_vd_2011.pdf114.81 kBAdobe PDFKüçük resim
Göster/Aç


Bu öğe kapsamında lisanslı Creative Commons License Creative Commons