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http://hdl.handle.net/11452/24548
Başlık: | Investigation of MMAC/PTEN gene mutations and protein expression in low grade gliomas |
Yazarlar: | Güler, Gülnur Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı. Uludağ Üniversitesi/Fen- Edebiyat Fakültesi/Biyoloji Anabilim Dalı. 0000-0002-7687-3284 0000-0001-7904-883X 0000-0002-1619-6680 0000-0002-3820-424X Çeçener, Gülşah Tunca, Berrin Egeli, Ünal Bekar, Ahmet Vatan, Özgür Tolunay, Şahsine AAI-1612-2021 O-7508-2015 AAH-1420-2021 ABI-6078-2020 AAP-9988-2020 6508156530 6602965754 55665145000 6603677218 16235098100 6602604390 |
Anahtar kelimeler: | IHC Low grade gliomas MMAC/PTEN Sequencing SSCP Turkish population Glioblastoma-multiforme Sequence-analysis Pten mutations Pten/mmac1 Cancer P53 Cell Biology Neurosciences & neurology |
Yayın Tarihi: | Tem-2009 |
Yayıncı: | Springer/Plenum Publishers |
Atıf: | Çeçener, G. vd. (2009). "Investigation of MMAC/PTEN gene mutations and protein expression in low grade gliomas". Cellular and Molecular Neurobiology, 29(5), 733-738. |
Özet: | The MMAC/PTEN tumor suppressor gene has an essential biological role in the formation of glioblastomas. It is known that there are variations in genetic alterations in tumors that develop in patients with different ethnic backgrounds; thus, we aimed to evaluate the incidence of MMAC/PTEN mutations and protein expression among various low grade gliomas of Turkish patients. We investigated 28 low grade gliomas for mutations of the MMAC/PTEN gene using single strand conformational polymorphism method followed by DNA sequencing. Additionally, the level of MMAC/PTEN protein expression in the tissues of 26 tumors was assessed by immunohistochemistry. In our investigation, MMAC/PTEN mutations were detected in 2 of 28 tumors (7.14%). One novel sequence variant G -> A transition at codon 159 was identified. This missense variation was a result of an alteration from AGG (Arginine) to AAG (Lysine). Moreover, it was observed that MMAC/PTEN protein expression was reduced to 73.08% of tumors. In conclusion, reduced MMAC/PTEN expression by genetic and/or epigenetic mechanisms in low grade gliomas might be associated with glioma tumorigenesis. |
URI: | https://doi.org/10.1007/s10571-009-9397-z https://link.springer.com/article/10.1007/s10571-009-9397-z http://hdl.handle.net/11452/24548 |
ISSN: | 0272-4340 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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