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Başlık: Lack of genotoxicity in medical oncology nurses handling antineoplastic drugs: Effect of work environment and protective equipment
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/ Tıp Fakültesi/Onkoloji Anabilim Dalı.
0000-0002-9732-5340
0000-0002-2382-290X
Gülten, Tuna
Evke, Elif
Ercan, İlker
Evrensel, Türkkan
Kurt, Ender
Manavoǧlu, Osman
AAJ-1027-2021
6505944216
8572204200
6603789069
6603942124
7006207332
6602587152
Anahtar kelimeler: Public,environmental & occupational health
Occupational exposure
Health care workers
Sister chromatid exchange assay
Closed system device
Biological monitoring
Sister-chromatid exchanges
Occupational-exposure
Anticancer drugs
Buccal cells
Dna-damage
Lymphocytes
Risk
Contamination
Chromosome
Induction
Yayın Tarihi: 2011
Yayıncı: IOS
Atıf: Gülten, T. vd. (2011). "Lack of genotoxicity in medical oncology nurses handling antineoplastic drugs: Effect of work environment and protective equipment". Work-A Journal of Prevention Assessment and Rehabilitation, 39(4), 485-489.
Özet: Objective: In this study we aimed to investigate the genotoxic effects of antineoplastic agents in occupationaly exposed oncology nurses. Genotoxic effects mean the disruptive effects in the integrity of DNA and they are associated with cancer development. Biomonitoring of health care workers handling antineoplastic agents is helpful for the evaluation of exposure to cytostatics. Participants: The study included an exposed and two control groups. The exposed group (n = 9) was comprised of oncology nurses. The first (n = 9) and second (n = 10) control groups were comprised of subjects who did not come into contact with antineoplastic drugs working respectively in the same department with oncology nurses and in different departments. Methods: Genotoxicity evaluation was performed using SCE analysis. After applying culture, harvest and chromosome staining procedures, a total of 25 metaphases were analyzed per person. Kruskal Wallis test was used to perform statistical analysis. Result: A statistically significant difference of sister chromatid exchange frequencies was not observed between the exposed and control groups. Conclusion: Lack of genotoxicity in medical oncology nurses might be due to good working conditions with high standards of technical equipment and improved personal protection.
URI: https://doi.org/10.3233/WOR-2011-1198
https://content.iospress.com/articles/work/wor01198
http://hdl.handle.net/11452/23973
ISSN: 1051-9815
1875-9270
Koleksiyonlarda Görünür:Scopus
Web of Science

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