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http://hdl.handle.net/11452/23151
Başlık: | The efficacy of serial serum amyloid A measurements for diagnosis and follow-up of necrotizing enterocolitis in premature infants |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı. 0000-0002-2148-1160 Çetinkaya, Merih Özkan, Hilal Köksal, Nilgün Akacı, Okan Özgür, Taner AAG-8393-2021 AAG-8381-2021 23994946300 16679325400 7003323615 36131105700 36087775800 |
Anahtar kelimeler: | Diagnosis Necrotizing enterocolitis Newborn Premature Serum amyloid A C-reactive protein Acute-phase proteins Neonatal sepsis Blood-count Disease Procalcitonin Parameters Management Responses Severity Pediatrics Surgery |
Yayın Tarihi: | Ağu-2010 |
Yayıncı: | Springer |
Atıf: | Çetinkaya, M. vd. (2010). "The efficacy of serial serum amyloid A measurements for diagnosis and follow-up of necrotizing enterocolitis in premature infants". Pediatric Surgery International, 26(8), 865-841. |
Özet: | The purpose of this study was to evaluate the efficacy of serial serum amyloid A (SAA) measurements in diagnosis and follow-up of necrotizing enterocolitis (NEC) in preterm infants. A total of 144 infants were enrolled in this observational study. The infants were classified into three groups: group 1 (infants with NEC and sepsis), group 2 (infants with sepsis), and group 3 (no sepsis and NEC, control group). Data including serial whole blood count (WBC), SAA measurements that were obtained at the initial work-up of NEC and/or sepsis episode (0 day), at 24, 48 h, 7, and 10 day were evaluated. In addition, initial and serial follow-up abdominal radiographies were obtained. A total of 50 infants were diagnosed NEC. Mean SAA values (43.2 +/- A 47.5 mg/dl) of infants in group 1 at 0 h were significantly higher than those in group 2 and group 3. The percentage of infants with abnormal SAA levels was significantly higher in group 1 compared with that in group 2 at 24 h. In addition, the percentage of infants with abnormal SAA levels was slightly but not statistically higher in stage 2 and stage 3 NEC group compared with that stage 1 NEC at 0, 24, 48 h. SAA levels started to decline at 48 h of onset through day 10. The cut-off value for SAA for differentiating NEC from sepsis was 23.2 mg/dl. SAA may be recognized as an accurate laboratory marker in addition to clinical and radiographic findings for NEC diagnosis. It can also be used for determining the severity of NEC and response to therapy in infants with NEC. |
URI: | https://doi.org/10.1007/s00383-010-2635-0 https://pubmed.ncbi.nlm.nih.gov/20574758/ http://hdl.handle.net/11452/23151 |
ISSN: | 0179-0358 1437-9813 Other Information |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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