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Başlık: Tetraiodothyroacetic acid and its nanoformulation inhibit thyroid hormone stimulation of non-small cell lung cancer cells in vitro and its growth in xenografts
Yazarlar: Mousa, Shaker A.
Bharali, Dhruba J.
Meng, Ran
Tang, Heng-Yuan
Lin, Hung-Yun
Davis, Faith B.
Davis, Paul J.
Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.
0000-0002-5600-8162
Yalçın, Murat
AAG-6956-2021
57192959734
Anahtar kelimeler: Oncology
Respiratory system
Non-small cell lung cancer
Thyroid hormone
Tetrac
Tetrac nanoparticles
Angiogenesis
Cell surface integrin alpha v beta 3 receptor
Cancer
Activated protein-kinase
Surface receptor
L-thyroxine
Integrin
Hypothyroidism
Carcinoma
Glioma
3,5,3'-triiodo-l-thyronine
Proliferation
Yayın Tarihi: Nis-2012
Yayıncı: Elsevier Ireland
Atıf: Mousa, S. A. vd. (2012). "Tetraiodothyroacetic acid and its nanoformulation inhibit thyroid hormone stimulation of non-small cell lung cancer cells in vitro and its growth in xenografts". Lung Cancer, 76(1), 39-45.
Özet: Thyroid hormone stimulates cell proliferation of several types of cancers and stimulates cancer-relevant angiogenesis. In the present study, we investigated the proliferative effect of thyroid hormone and the anti-proliferative and anti-angiogenic action of its nano-derivative, tetrac-NP, on human non-small cell lung cancer (NSCLC) H1299 cells in vitro and in xenografts. The anti-proliferative activity of unmodified tetrac and tetrac-NP against human H1299 cells was determined in three models: (a) cultured H1299 cells in vitro, (b) tumor cell implants in the fertilized chick chorioallantoic membrane (CAM) system and (c) xenografts in the nude mouse. An integrin alpha v beta 3 antibody inhibited thyroid hormone-induced cell proliferation in vitro, as did unmodified tetrac and tetrac-NP. Pharmacologic inhibition of the mitogen-activated protein kinase pathway also blocked NSCLC cell proliferation in response to thyroid hormone. Tetrac and tetrac-NP arrested tumor growth and tumor-related angiogenesis in H1299 cells grown in the CAM model and both agents prevented chick embryo mortality. Xenografts of H1299 cells were established in nude mice (n = 8, treatment and control groups) and when tumor volumes reached 250-300 mm(3), tetrac (1 mg/kg) or tetrac-NP (1 mg tetrac as the nanoparticle/kg) were administered intraperitoneally every 2 days. Tetrac and tetrac-NP significantly suppressed tumor growth and angiogenesis. Thus, both tetrac and tetrac-NP effectively arrest human NSCLC tumor cell proliferation in vitro and in the CAM assay and in murine xenograft models.
URI: https://doi.org/10.1016/j.lungcan.2011.10.003
https://pubmed.ncbi.nlm.nih.gov/22024450/
https://www.sciencedirect.com/science/article/pii/S0169500211005162
http://hdl.handle.net/11452/22888
ISSN: 0169-5002
1872-8332
Koleksiyonlarda Görünür:Scopus
Web of Science

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