1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/34812
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dc.contributor.authorGiray, Aslı-
dc.contributor.authorKarakaş, Bahriye-
dc.contributor.authorGül, Özgür-
dc.contributor.authorKozanoğlu, İlknur-
dc.contributor.authorÇelik, Hüsnü-
dc.contributor.authorBaşağa, Hüveyda-
dc.contributor.authorAçıkbaş, Ufuk-
dc.contributor.authorSuçularlı, Ceren-
dc.contributor.authorÖztop, Sıdıka-
dc.contributor.authorAka, Yeliz-
dc.contributor.authorKütük, Özgür-
dc.date.accessioned2023-11-09T06:40:13Z-
dc.date.available2023-11-09T06:40:13Z-
dc.date.issued2020-12-
dc.identifier.citationTemel, S. G. vd. (2020). ''RAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cells''. Apoptosis, 25(11-12), 799-816.en_US
dc.identifier.issn1360-8185-
dc.identifier.issn1573-675X-
dc.identifier.urihttps://doi.org/10.1007/s10495-020-01635-z-
dc.identifier.urihttps://link.springer.com/article/10.1007/s10495-020-01635-z-
dc.identifier.urihttp://hdl.handle.net/11452/34812-
dc.description.abstractOvarian cancer remains one of the most frequent causes of cancer-related death in women. Many patients with ovarian cancer suffer from de novo or acquired resistance to chemotherapy. Here, we report that RAB25 suppresses chemotherapy-induced mitochondrial apoptosis signaling in ovarian cancer cell lines and primary ovarian cancer cells. RAB25 blocks chemotherapy-induced apoptosis upstream of mitochondrial outer membrane permeabilization by either increasing antiapoptotic BCL-2 proteins or decreasing proapoptotic BCL-2 proteins. In particular, BAX expression negatively correlates with RAB25 expression in ovarian cancer cells. BH3 profiling assays corroborated that RAB25 decreases mitochondrial cell death priming. Suppressing RAB25 by means of RNAi or RFP14 inhibitory hydrocarbon-stapled peptide sensitizes ovarian cancer cells to chemotherapy as well as RAB25-mediated proliferation, invasion and migration. Our data suggest that RAB25 is a potential therapeutic target for ovarian cancer.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TUBITAK) (113S871)tr_TR
dc.description.sponsorshipBaşkent Üniversitesitr_TR
dc.description.sponsorshipScience Academy BAGEP programtr_TR
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRab25en_US
dc.subjectChemotherapyen_US
dc.subjectBcl-2 proteinsen_US
dc.subjectOvarian canceren_US
dc.subjectBcl-2en_US
dc.subjectExpressionen_US
dc.subjectMetasisen_US
dc.subjectInhibitionen_US
dc.subjectInvasionen_US
dc.subjectOverexpressionen_US
dc.subjectProliferationen_US
dc.subjectContributesen_US
dc.subjectBiomarkersen_US
dc.subjectKidneyen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCell biologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshApoptosisen_US
dc.subject.meshCell cycleen_US
dc.subject.meshCell lineen_US
dc.subject.meshTumoren_US
dc.subject.meshCell movementen_US
dc.subject.meshCell proliferationen_US
dc.subject.meshDrug resistanceen_US
dc.subject.meshNeoplasmen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMitochondriaen_US
dc.subject.meshNeoplasm invasivenessen_US
dc.subject.meshOvarian neoplasmsen_US
dc.subject.meshProto-oncogene proteins c-bcl-2en_US
dc.subject.meshRab gtp-binding proteinsen_US
dc.subject.meshSignal transductionen_US
dc.titleRAB25 confers resistance to chemotherapy by altering mitochondrial apoptosis signaling in ovarian cancer cellsen_US
dc.typeArticleen_US
dc.identifier.wos000567421400001tr_TR
dc.identifier.scopus2-s2.0-85090440803tr_TR
dc.relation.tubitakTÜBİTAKtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Bölümütr_TR
dc.contributor.orcid0000-0002-9802-0880tr_TR
dc.identifier.startpage799tr_TR
dc.identifier.endpage816tr_TR
dc.identifier.volume25tr_TR
dc.identifier.issue11-12tr_TR
dc.relation.journalApoptosisen_US
dc.contributor.buuauthorTemel, Şehime Gülsün-
dc.contributor.researcheridAAG-8385-2021tr_TR
dc.relation.collaborationYurt içitr_TR
dc.identifier.pubmed32901335tr_TR
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosCell biologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid6507885442tr_TR
dc.subject.scopusRab GTP-binding Protein; Carrier Proteins; Endosomesen_US
dc.subject.emtreeBh3 proteinen_US
dc.subject.emtreeBim proteinen_US
dc.subject.emtreeCarboplatinen_US
dc.subject.emtreeCaspase 3en_US
dc.subject.emtreeCapace 9en_US
dc.subject.emtreeEtoposideen_US
dc.subject.emtreeHydrocarbonen_US
dc.subject.emtreePaclitaxelen_US
dc.subject.emtreeProtein baxen_US
dc.subject.emtreeProtein bcl 2en_US
dc.subject.emtreeProtein mcl 1en_US
dc.subject.emtreeProtein noxaen_US
dc.subject.emtreePuma proteinen_US
dc.subject.emtreeRab proteinen_US
dc.subject.emtreeRab25 proteintr_TR
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeProtein bcl 2en_US
dc.subject.emtreeRab proteinen_US
dc.subject.emtreeRab25 protein, humanen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAmino acid sequenceen_US
dc.subject.emtreeApoptosisen_US
dc.subject.emtreeApoptosis asseyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer cellen_US
dc.subject.emtreeCancer combination chemotherapyen_US
dc.subject.emtreeCancer gradingen_US
dc.subject.emtreeCancer patienten_US
dc.subject.emtreeCancer resistanceen_US
dc.subject.emtreeCell fractionationen_US
dc.subject.emtreeCell invasionen_US
dc.subject.emtreeCell migrationen_US
dc.subject.emtreeCell proliferationen_US
dc.subject.emtreeCell proliferation assayen_US
dc.subject.emtreeCell viabilityen_US
dc.subject.emtreeChemoluminescenceen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeData analysis softwareen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFlow cytometryen_US
dc.subject.emtreeFluorometryen_US
dc.subject.emtreeGene expression levelen_US
dc.subject.emtreeHEY A8 cell lineen_US
dc.subject.emtreeHistologyen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeIgrov-1 cell lineen_US
dc.subject.emtreeLow drug doseen_US
dc.subject.emtreeMitochondrionen_US
dc.subject.emtreeOuter membraneen_US
dc.subject.emtreeOvary canceren_US
dc.subject.emtreeOvcar-3 cell lineen_US
dc.subject.emtreeOvcar-4 cell lineen_US
dc.subject.emtreeOvcar-5 cell lineen_US
dc.subject.emtreeOvcar-8 cell lineen_US
dc.subject.emtreeOverall survivalen_US
dc.subject.emtreePolyacrylamide gel electrophoresisen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProgression free survivalen_US
dc.subject.emtreeProtein depletionen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeProtein isolationen_US
dc.subject.emtreeReal time polymerase chain reactionen_US
dc.subject.emtreeRna interferenceen_US
dc.subject.emtreeScanning electron microscopyen_US
dc.subject.emtreeSk-ov-3 cell lineen_US
dc.subject.emtreeThree dimensional cell cultureen_US
dc.subject.emtreeTov-112D cell lineen_US
dc.subject.emtreeCell cycleen_US
dc.subject.emtreeCell motionen_US
dc.subject.emtreeDrug resistanceen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMitochondrionen_US
dc.subject.emtreeOvary tumoren_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeSignal transductionen_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.emtreeTumor invasionen_US
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