Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/33874
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dc.date.accessioned2023-09-18T12:03:06Z-
dc.date.available2023-09-18T12:03:06Z-
dc.date.issued2014-
dc.identifier.citationYılmaz, E. vd. (2014). "Increased serum hepcidin levels in Brucellosis". Clinical Laboratory, 60(11), 1837-1843.en_US
dc.identifier.issn1433-6510-
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2014.131209-
dc.identifier.urihttps://www.clin-lab-publications.com/article/1658-
dc.identifier.urihttp://hdl.handle.net/11452/33874-
dc.description.abstractBackground: Both CD4(+) and CD8(+) T lymphocytes play crucial roles in immunity to Brucella, in part because they secrete interferon (IFN)-gamma and activate the bactericidal functions in macrophages. Hepcidin is an antimicrobial and iron regulatory peptide produced by the liver in response to inflammation and elevated systemic iron. Recent studies suggest that circulating monocytes and resident liver macrophages may influence both basal and inflammatory expression of hepcidin and these two cell types act in concert to regulate hepcidin production during inflammation. Here, we aimed to investigate the association of hepcidin levels with Brucellosis. Methods: Serum hepcidin levels in 49 Brucellosis patients were compared with 52 healthy control subjects by commercial ELISA kit. Results: The levels of serum hepcidin were significantly higher in Brucellosis patients compared with those of healthy controls (p < 0.001). There was no statistically significant difference in serum hepcidin levels among acute, subacute, and chronic cases with Brucellosis. Hepcidin levels were positively correlated with CRP in patients with brucellosis. Conclusions: Our first results may suggest that the levels of Hepcidin may be a useful adjunct to clinical and other laboratory findings suggestive of the disease for the diagnosis of Brucellosis, but cannot be used to differentiate the three different forms of this disease (acute, subacute, and chronic).en_US
dc.language.isoenen_US
dc.publisherClin Lab Publicationen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectHepcidinen_US
dc.subjectBrucellaen_US
dc.subjectAntimicrobial peptide hepcidinen_US
dc.subjectGamma-interferonen_US
dc.subjectMacrophagesen_US
dc.subjectIron homeostasisen_US
dc.subjectImmunityen_US
dc.subjectExpressionen_US
dc.subjectInflammationen_US
dc.subjectInfectionen_US
dc.subjectAbortusen_US
dc.subjectAnemiaen_US
dc.subjectMedical laboratory technologyen_US
dc.subject.meshAcute diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshArea under curveen_US
dc.subject.meshBiological markersen_US
dc.subject.meshBrucellosisen_US
dc.subject.meshC-reactive proteinen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshChronic diseaseen_US
dc.subject.meshEnzyme-linked immunosorbent assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepcidinsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPredictive value of testsen_US
dc.subject.meshRoc curveen_US
dc.subject.meshUp-regulationen_US
dc.titleIncreased serum hepcidin levels in Brucellosisen_US
dc.typeArticleen_US
dc.identifier.wos000344911700008tr_TR
dc.identifier.scopus2-s2.0-85006626458tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0001-7625-9148tr_TR
dc.contributor.orcid0000-0002-3894-1231tr_TR
dc.identifier.startpage1837tr_TR
dc.identifier.endpage1843tr_TR
dc.identifier.volume60tr_TR
dc.identifier.issue11tr_TR
dc.relation.journalClinical Laboratoryen_US
dc.contributor.buuauthorYılmaz, Emel-
dc.contributor.buuauthorAyarcı, Ayşe Oǧuz-
dc.contributor.buuauthorSığırlı, Deniz-
dc.contributor.buuauthorTorlar, Meltem Öner-
dc.contributor.buuauthorBudak, Ferah Ah-
dc.contributor.buuauthorGöral, Güher-
dc.contributor.buuauthorOral, Haluk Barbaros-
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridAAA-7472-2021tr_TR
dc.identifier.pubmed25648024tr_TR
dc.subject.wosMedical laboratory technologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid22037135100tr_TR
dc.contributor.scopusid55589179100tr_TR
dc.contributor.scopusid56436583600tr_TR
dc.contributor.scopusid56436661700tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid6603453166tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.subject.scopusHepcidins; Anemia; Iron-Refractory Iron Deficiency Anemiaen_US
dc.subject.emtreeAcute diseaseen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArea under the curveen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeBrucellosisen_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeChronic diseaseen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMicrobiologyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePredictive valueen_US
dc.subject.emtreeReceiver operating characteristicen_US
dc.subject.emtreeUpregulationen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeHepcidinen_US
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