Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/33154
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dc.date.accessioned2023-06-23T11:45:02Z-
dc.date.available2023-06-23T11:45:02Z-
dc.date.issued2013-02-
dc.identifier.citationAyarcı, A. O. vd. (2013). “Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis”. Microbiology and Immunology, 57(2), 150-158.en_US
dc.identifier.issn0385-5600-
dc.identifier.issn1348-0421-
dc.identifier.urihttps://doi.org/10.1111/1348-0421.12016-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/1348-0421.12016-
dc.identifier.urihttp://hdl.handle.net/11452/33154-
dc.description.abstractBoth cluster of differentiation (CD)4+ and CD8+ T lymphocytes play key roles in immunity to Brucella, in part because they secrete interferon (IFN)- and activate bactericidal functions in macrophages. Therefore, use of markers of macrophage activation may have diagnostic and prognostic significance. High-mobility group-box 1 protein (HMGB1), a late-onset pro-inflammatory cytokine, is secreted by activated macrophages. Soluble hemoglobin scavenger receptor (sCD163) is a specific marker of anti-inflammatory macrophages. The aim of this study was to investigate the diagnostic value of HMGB1 and sCD163 concentrations in brucellosis and its various clinical forms. Serum HMGB1 and sCD163 concentrations in 49 brucellosis patients were compared with those in 52 healthy control subjects. Both serum HMGB1 and sCD163 concentrations were significantly higher in brucellosis patients than in healthy controls (P<0.001). There were no statistically significant differences in serum concentrations of HMGB1 and sCD163 between cases of acute, subacute and chronic brucellosis. Additionally, serum HMGB1 concentrations were positively correlated with sCD163 concentrations, whereas neither HMGB1 nor sCD163 concentrations were correlated with C-reactive protein concentrations, white cell counts or erythrocyte sedimentation rates. Therefore, serum concentrations of HMGB1 and sCD163 may be diagnostic markers for brucellosis, but neither can be used to differentiate the three different forms of this disease (acute, subacute and chronic).en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectImmunologyen_US
dc.subjectMicrobiologyen_US
dc.subjectBrucellaen_US
dc.subjectHigh-mobility group-box 1 proteinen_US
dc.subjectImmunityen_US
dc.subjectSoluble hemoglobin scavenger receptoren_US
dc.subjectCommunity-acquired infectionsen_US
dc.subjectLipopolysaccharide-binding proteinen_US
dc.subjectAlternative activationen_US
dc.subjectLate mediatoren_US
dc.subjectCD163 levelsen_US
dc.subjectHMGB1en_US
dc.subjectBacteremiaen_US
dc.subjectMarkersen_US
dc.subjectChildrenen_US
dc.subjectSepsisen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, CDen_US
dc.subject.meshAntigens, differentiation, myelomonocyticen_US
dc.subject.meshBiological markersen_US
dc.subject.meshBlood sedimentationen_US
dc.subject.meshBrucellaen_US
dc.subject.meshBrucellosisen_US
dc.subject.meshC-reactive proteinen_US
dc.subject.meshFemaleen_US
dc.subject.meshHMGB1 proteinen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukocyte counten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshReceptors, cell surfaceen_US
dc.subject.meshSerumen_US
dc.titleDiagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosisen_US
dc.typeArticleen_US
dc.identifier.wos000314984100010tr_TR
dc.identifier.scopus2-s2.0-84873732101tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Bölümü.tr_TR
dc.relation.bapUAP(T)-2010/04tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0002-3894-1231tr_TR
dc.identifier.startpage150tr_TR
dc.identifier.endpage158tr_TR
dc.identifier.volume57tr_TR
dc.identifier.issue2tr_TR
dc.relation.journalMicrobiology and Immunologyen_US
dc.contributor.buuauthorAyarcı, Ayşe Oǧuz-
dc.contributor.buuauthorYılmaz, Emel-
dc.contributor.buuauthorSığırlı, Deniz-
dc.contributor.buuauthorBudak, Ferah Ah-
dc.contributor.buuauthorGöral, Güher-
dc.contributor.buuauthorOral, Haluk Barbaros-
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridAAA-7472-2021tr_TR
dc.identifier.pubmed23278480tr_TR
dc.subject.wosImmunologyen_US
dc.subject.wosMicrobiologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ4en_US
dc.contributor.scopusid55589179100tr_TR
dc.contributor.scopusid22037135100tr_TR
dc.contributor.scopusid24482063400tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid6603453166tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.subject.scopusMacrophage; Macrophage Activation; Haptoglobin-Hemoglobin Complexen_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeCD163 antigenen_US
dc.subject.emtreeHigh mobility group B1 proteinen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood samplingen_US
dc.subject.emtreeBrucellaen_US
dc.subject.emtreeBrucellosisen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeDiagnostic test accuracy studyen_US
dc.subject.emtreeDiagnostic valueen_US
dc.subject.emtreeDifferential diagnosisen_US
dc.subject.emtreeDisease markeren_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeErythrocyte sedimentation rateen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeLeukocyte counten_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNephelometryen_US
dc.subject.emtreeProtein analysisen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeProtein functionen_US
dc.subject.emtreeReceiver operating characteristicen_US
dc.subject.emtreeReference valueen_US
dc.subject.emtreeSensitivity and specificityen_US
dc.subject.emtreeSymptomatologyen_US
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