Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/33005
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dc.contributor.authorKoç, Mehmet-
dc.date.accessioned2023-06-12T06:09:56Z-
dc.date.available2023-06-12T06:09:56Z-
dc.date.issued2003-
dc.identifier.citationKoç, M. vd. (2003). “Therapeutic effect of oral recombinant human granulocyte macrophage-colony stimulating factor in radiotherapy-induced esophagitis”. Hepato-Gastroenterology, 50(53), 1297-1300.en_US
dc.identifier.issn0172-6390-
dc.identifier.urihttp://hdl.handle.net/11452/33005-
dc.descriptionBu çalışma, 25-30 Kasım 2001 tarihleri arasında Illinois[Amerika Birleşik Devletleri]’nde düzenlenen 87. Scientific Assembly and Annual Meeting of the Radiological-Society-of-North-America’da bildiri olarak sunulmuştur.tr_TR
dc.description.abstractBackground/Aims: Radiation-induced esophagitis is one of the most important early side effects of irradiation of chest, and head and neck malignancies. This condition often leads to interruption of radiotherapy for several days. An effective treatment for reducing the incidence and, severity of this complication has not yet been found: We aimed to investigate the therapeutic effect of rhGM-CSF, on radiation-induced esophagitis in the patients with chest or head and neck malignancies. Methodology: Ninety-seven patients with chest or head and neck malignancies who had not previously received radiation therapy, were treated with radiotherapy, concurrent or sequential chemoradiotherapy. Forty-eight patients who had grade 1, 2 or 3 esophagitis symptoms according to Radiation Therapy Oncology Group radiation morbidity score, underwent upper gastrointestinal endoscopy. In the patients with grade 3, esophagitis (according to Kuwahata's scoring system) rhGM-CSF was administered for 5-10 consecutive days as an oral solution. Results: Endoscopic examinations showed grade 3 esophagitis in 26 of. these patients according to Kuwahata's score. Twenty-five patients with grade 3 esophagitis were given rhGM-CSF therapy. Radio-therapy was continued in 23 patients. After the rhGM-CSF therapy; esophagitis had regressed from grade 3 to grade 0 in 10 (43%), from grade 3 to grade 1 in 8 (35%), and from grade 3 to grade 2 in 3 patients (12%). Two patients (9%) did not respond to rhGM-CSF therapy. Twenty-one patients (91%) completed planned radiotherapy without interruption. Conclusions In patients with radiation-induced esophagitis, ulcerated esophageal mucosa healed with local granulocyte macrophage-colony stimulating factor administration in median 8 days without radiotherapy interruption.en_US
dc.description.sponsorshipRadiol Soc N Ameren_US
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastroenterology and hepatologyen_US
dc.subjectSurgeryen_US
dc.subjectRadiation-induced esophagitisen_US
dc.subjectChest or head and neck irradiationen_US
dc.subjectOral rhGM-CSF treatmenten_US
dc.subjectCell lung-canceren_US
dc.subjectFactor GM-CSFen_US
dc.subjectRadiation-therapyen_US
dc.subjectMucositisen_US
dc.subjectChemotherapyen_US
dc.subjectTrialen_US
dc.subjectHeaden_US
dc.subjectIrradiationen_US
dc.subjectCarcinomaen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, non-small-cell lungen_US
dc.subject.meshCarcinoma, small cellen_US
dc.subject.meshEsophagitisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGranulocyte-macrophage colony-stimulating factoren_US
dc.subject.meshHead and neck neoplasmsen_US
dc.subject.meshHumansen_US
dc.subject.meshLung neoplasmsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshRadiation injuriesen_US
dc.subject.meshRecombinant proteinsen_US
dc.titleTherapeutic effect of oral recombinant human granulocyte macrophage-colony stimulating factor in radiotherapy-induced esophagitisen_US
dc.typeArticleen_US
dc.typeProceedings Paperen_US
dc.identifier.wos000185549200026tr_TR
dc.identifier.scopus2-s2.0-0141763605tr_TR
dc.relation.publicationcategoryKonferans Öğesi - Uluslararasıtr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.identifier.startpage1297tr_TR
dc.identifier.endpage1300tr_TR
dc.identifier.volume50tr_TR
dc.identifier.issue53tr_TR
dc.relation.journalHepato-Gastroenterologyen_US
dc.contributor.buuauthorOnuk, Mehmet Derya-
dc.contributor.buuauthorKoruk, Mehmet-
dc.contributor.buuauthorMemik, Faruk-
dc.contributor.researcheridHJA-2650-2022tr_TR
dc.relation.collaborationYurt içitr_TR
dc.identifier.pubmed14571722tr_TR
dc.subject.wosGastroenterology and hepatologyen_US
dc.subject.wosSurgeryen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosCPCISen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.contributor.scopusid6602809456tr_TR
dc.contributor.scopusid56088745300tr_TR
dc.contributor.scopusid6701813462tr_TR
dc.subject.scopusStomatitis; Mucositis; Chemotherapyen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer combination chemotherapyen_US
dc.subject.emtreeCancer patienten_US
dc.subject.emtreeCancer radiotherapyen_US
dc.subject.emtreeClinical protocolen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease classificationen_US
dc.subject.emtreeEsophagitisen_US
dc.subject.emtreeEsophagus mucosaen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGastroscopyen_US
dc.subject.emtreeHead and neck carcinomaen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRadiation injuryen_US
dc.subject.emtreeRemissionen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeUlcer healingen_US
dc.subject.emtreeRecombinant granulocyte colony stimulating factoren_US
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