Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30618
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dc.contributor.authorGutenberg, Angelina-
dc.contributor.authorGunawan, Bastian-
dc.contributor.authorSchulten, Hans Jurgen-
dc.date.accessioned2023-01-23T13:26:33Z-
dc.date.available2023-01-23T13:26:33Z-
dc.date.issued2007-05-01-
dc.identifier.citationYakut, T. vd. (2007). "Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas". Oncology Reports, 17(5), 1037-1043.en_US
dc.identifier.issn1021-335X-
dc.identifier.urihttps://doi.org/10.3892/or.17.5.1037-
dc.identifier.urihttps://www.spandidos-publications.com/10.3892/or.17.5.1037-
dc.identifier.urihttp://hdl.handle.net/11452/30618-
dc.description.abstractThe histological subclassification of gliomas is increasingly assisted by the underlying molecular genetics which has major importance in guiding clinical management of the disease. However, the assessment of several molecular events for improving clinical care remains a challenge. Herein, we report on comparative genomic hybridization (CGH) and immunohistochemical (IHC) assessment of EGFR, PTEN, p53, and MIB-1 expression in 13 oligodendrogliomas (10 WHO grade II, 3 WHO grade III), one oligoastrocytoma (WHO grade III) and 23 high-grade astrocytomas Q WHO grade III, 20 glioblastoma multiforme). The most frequent imbalances in oligodendroglial tumors including the oligoastrocytic case were, in decreasing order of frequency, +7q, -1p, and -4q and in astrocytomas +7q, -10q, +7p, -9p, -10p, +20q, and +20p. Some individual imbalances were associated with increasing numbers of chromosomal changes, that were +7q in both oligodendrogliomas and astrocytomas, and -9p, -10q, +20p, and +20q in astrocytomas. The markers p53 and MIB-1 were significantly higher expressed in astrocytomas than in oligodendrogliomas and expression levels of p53 and EGFR were inversely associated within the astrocytic group. In addition, p53 overexpression correlated positively with +7q and negatively with -1p in the oligodendroglial group whereas EGFR overexpression correlated positively with -1p in the oligodendroglial and positively with +7p and -10p in the astrocytic group. Short overall survival was significantly associated with +7p and -10q in astrocytomas. Collectively, these results contribute to the increasing clinical relevance of assessing tumor biological markers in gliomas.en_US
dc.language.isoenen_US
dc.publisherSpandidos Publicationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectComparative genomic hybridizationen_US
dc.subjectOncologyen_US
dc.subjectMolecular-genetic analysisen_US
dc.subjectAstrocytomasen_US
dc.subjectImmunohistochemistryen_US
dc.subjectOligodendrogliomasen_US
dc.subjectHigh-grade gliomasen_US
dc.subjectOligodendroglial tumorsen_US
dc.subjectGlioblastoma-multiformeen_US
dc.subjectAstrocytomasen_US
dc.subject19Qen_US
dc.subject1Pen_US
dc.subjectDiagnosisen_US
dc.subjectOverexpressionen_US
dc.subjectAmplificationen_US
dc.subject.meshNucleic acid hybridizationen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshChromosome aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGliomaen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPTEN phosphohydrolaseen_US
dc.subject.meshReceptor, epidermal growth factoren_US
dc.subject.meshTumor suppressor protein p53en_US
dc.subject.meshUbiquitin-protein ligasesen_US
dc.titleCorrelation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomasen_US
dc.typeArticleen_US
dc.identifier.wos000245855800009tr_TR
dc.identifier.scopus2-s2.0-34548544861tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genetik ve Moleküler Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroşirurji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Bioistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.identifier.startpage1037tr_TR
dc.identifier.endpage1043tr_TR
dc.identifier.volume17tr_TR
dc.identifier.issue5tr_TR
dc.relation.journalOncology Reportsen_US
dc.contributor.buuauthorYakut, Tahsin-
dc.contributor.buuauthorBekar, Ahmet-
dc.contributor.buuauthorEgeli, Ünal-
dc.contributor.buuauthorDoygun, Muammer-
dc.contributor.buuauthorTolunay, Şahsene-
dc.contributor.buuauthorErcan, İlker-
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed17390041tr_TR
dc.subject.wosOncologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid6603677218tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid6602604390tr_TR
dc.contributor.scopusid6507050239tr_TR
dc.subject.scopusOligodendroglioma; Procarbazine; Gliomaen_US
dc.subject.emtreeMIB1 protein, humanen_US
dc.subject.emtreeEpidermal growth factor receptoren_US
dc.subject.emtreeHER1 protein, humanen_US
dc.subject.emtreePTEN protein, humanen_US
dc.subject.emtreePhosphatidylinositol 3,4,5 trisphosphate 3 phosphataseen_US
dc.subject.emtreeProtein p53en_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeUbiquitin protein ligaseen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeNucleic acid hybridizationen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeBiosynthesisen_US
dc.subject.emtreePreschool childen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeMethodologyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeChromosome aberrationen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeGliomaen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInfanten_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreePathologyen_US
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