Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29866
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dc.contributor.authorİnan, Oya Eralp-
dc.contributor.authorBaykal, Ahmet T.-
dc.contributor.authorHacariz, O.-
dc.contributor.authorHatipoğlu, I.-
dc.contributor.authorTvarijonaviciute, Asta-
dc.contributor.authorCeron, Jose-
dc.contributor.authorUlus, İsmail Hakkı-
dc.date.accessioned2022-12-14T05:53:26Z-
dc.date.available2022-12-14T05:53:26Z-
dc.date.issued2016-09-10-
dc.identifier.citationYılmaz, Z. vd. (2016). "Changes in serum proteins after endotoxin administration in healthy and choline-treated calves". BMC Veterinary Research, 12.en_US
dc.identifier.issn1746-6148-
dc.identifier.urihttps://doi.org/10.1186/s12917-016-0837-y-
dc.identifier.urihttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-016-0837-y-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028968/-
dc.identifier.urihttp://hdl.handle.net/11452/29866-
dc.description.abstractBackground: This study aimed to investigate the possible serum protein changes after endotoxin administration in healthy and choline-treated calves using proteomics. These results are expected to contribute to the understanding of the pathophysiological mechanisms of endotoxemia and the beneficial effect of choline administration in this clinical situation. Methods: Healthy-calves (n = 20) were divided into 4 groups: Control, Choline treated (C), Lipopolysaccharide administered (LPS), and LPS + C. Control calves received 0.9 % NaCl injection. Calves in C and LPS + C groups received choline chloride (1 mg/kg/iv). Endotoxin (LPS) was injected (2 mu g/kg/iv) to the calves in LPS and LPS + C groups. Serum samples were collected before and after the treatments. Differentially expressed proteins (> 1.5 fold-change relative to controls) were identified by LC-MS/MS. Results: After LPS administration, 14 proteins increased, and 13 proteins decreased within 48 h as compared to controls. In the LPS group, there were significant increases in serum levels of ragulator complex protein (189-fold) and galectin-3-binding protein (10-fold), but transcription factor MafF and corticosteroid binding globulin were down regulated (>= 5 fold). As compared with the LPS group, in LPS + C group, fibrinogen gamma-B-chain and antithrombin were up-regulated, while hemopexin and histone H4 were down-regulated. Choline treatment attenuated actin alpha cardiac muscle-1 overexpression after LPS. Conclusions: LPS administration produces changes in serum proteins associated with lipid metabolism, immune and inflammatory response, protein binding/transport, cell adhesion, venous thrombosis, cardiac contractility and blood coagulation. The administration of choline is associated with changes in proteins which can be related with its beneficial effect in this clinical situation.en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectVeterinary sciencesen_US
dc.subjectCalvesen_US
dc.subjectCholineen_US
dc.subjectEndotoxemiaen_US
dc.subjectProteomicen_US
dc.subjectSepsisen_US
dc.subjectSystemic inflammatory responseen_US
dc.subjectGalectin-3-binding proteinen_US
dc.subjectFasciola-hepaticaen_US
dc.subjectNeonatal calvesen_US
dc.subjectSepsisen_US
dc.subjectHemopexinen_US
dc.subjectReleaseen_US
dc.subjectDogsen_US
dc.subjectIdentificationen_US
dc.subjectHaptoglobinen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood proteinsen_US
dc.subject.meshCattleen_US
dc.subject.meshCholineen_US
dc.subject.meshDown-regulationen_US
dc.subject.meshEndotoxinsen_US
dc.subject.meshGene expression regulationen_US
dc.subject.meshLipotropic agentsen_US
dc.subject.meshPilot projectsen_US
dc.subject.meshProteomicsen_US
dc.titleChanges in serum proteins after endotoxin administration in healthy and choline-treated calvesen_US
dc.typeArticleen_US
dc.identifier.wos000384379300003tr_TR
dc.identifier.scopus2-s2.0-84988511960tr_TR
dc.relation.tubitakTOVAG-111O026en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Eczacılık Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.identifier.volume12tr_TR
dc.relation.journalBMC Veterinary Researchen_US
dc.contributor.buuauthorYılmaz, Zeki-
dc.contributor.buuauthorCansev, Mehmet-
dc.contributor.buuauthorKocatürk, Meriç-
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.researcheridV-5578-2017tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed27646125tr_TR
dc.subject.wosVeterinary sciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.contributor.scopusid35944810500tr_TR
dc.contributor.scopusid36437200800tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.subject.scopusFasciola Hepatica; Fascioliasis; Animalsen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeEndotoxinen_US
dc.subject.emtreeLipotropic agenten_US
dc.subject.emtreePlasma proteinen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeBovineen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDown regulationen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeGene expression regulationen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreePilot studyen_US
dc.subject.emtreeProteomicsen_US
dc.subject.emtreeRandomized controlled trialen_US
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