Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29428
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dc.contributor.authorGajic, Ognien-
dc.contributor.authorDabbagh, Ousama-
dc.contributor.authorPark, Pauline K.-
dc.contributor.authorAdesanya, Adebola-
dc.contributor.authorChang, Steven Y.-
dc.contributor.authorHou, Peter-
dc.contributor.authorAnderson, Harry, III-
dc.contributor.authorHoth, J. Jason-
dc.contributor.authorMikkelsen, Mark E.-
dc.contributor.authorGentile, Nina T.-
dc.contributor.authorGong, Michelle N.-
dc.contributor.authorTalmor, Daniel-
dc.contributor.authorBajwa, Ednan-
dc.contributor.authorWatkins, Timothy R.-
dc.contributor.authorFestic, Emir-
dc.contributor.authorYılmaz, Murat-
dc.contributor.authorKaufman, David A.-
dc.contributor.authorEsper, Annette M.-
dc.contributor.authorSadikot, Ruxana-
dc.contributor.authorDouglas, Ivor-
dc.contributor.authorSevransky, Jonathan-
dc.contributor.authorMalinchoc, Michael-
dc.date.accessioned2022-11-08T11:50:07Z-
dc.date.available2022-11-08T11:50:07Z-
dc.date.issued2011-02-
dc.identifier.citationGajic, O. vd. (2011). "Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study". American Journal of Respiratory and Critical Care Medicine, 183(4), 462-470.en_US
dc.identifier.issn1073-449X-
dc.identifier.issn1535-4970-
dc.identifier.urihttps://doi.org/10.1164/rccm.201004-0549OC-
dc.identifier.urihttps://www.atsjournals.org/doi/full/10.1164/rccm.201004-0549OC-
dc.identifier.urihttp://hdl.handle.net/11452/29428-
dc.description.abstractRationale: Accurate, early identification of patients at risk for developing acute lung injury (ALI) provides the opportunity to test and implement secondary prevention strategies. Objectives: To determine the frequency and outcome of ALI development in patients at risk and validate a lung injury prediction score (LIPS). Methods: In this prospective multicenter observational cohort study, predisposing conditions and risk modifiers predictive of ALI development were identified from routine clinical data available during initial evaluation. The discrimination of the model was assessed with area under receiver operating curve (AUC). The risk of death from ALI was determined after adjustment for severity of illness and predisposing conditions. Measurements and Main Results: Twenty-two hospitals enrolled 5,584 patients at risk All developed a median of 2 (interquartile range 1-4) days after initial evaluation in 377 (6.8%; 148 ALI-only, 229 adult respiratory distress syndrome) patients. The frequency of ALI varied according to predisposing conditions (from 3% in pancreatitis to 26% after smoke inhalation). LIPS discriminated patients who developed ALI from those who did not with an AUC of 0.80(95% confidence interval, 0.78-0.82). When adjusted for severity of illness and predisposing conditions, development of ALI increased the risk of in-hospital death (odds ratio, 4.1; 95% confidence interval, 2.9-5.7). Conclusions: ALI occurrence varies according to predisposing conditions and carries an independently poor prognosis. Using routinely available clinical data, LIPS identifies patients at high risk for ALI early in the course of their illness. This model will alert clinicians about the risk of ALI and facilitate testing and implementation of ALI prevention strategies.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA HL78743-01A1, 1 KL2 RR024151en_US
dc.description.sponsorshipMayo Clinic Critical Care Research Committeeen_US
dc.description.sponsorshipSanofi-Aventisen_US
dc.description.sponsorshipPfizeren_US
dc.description.sponsorshipUniversity of Missourien_US
dc.description.sponsorshipVital Therapiesen_US
dc.description.sponsorshipMaquet Inc.en_US
dc.description.sponsorshipEli Lillyen_US
dc.description.sponsorshipArtisan Pharmaen_US
dc.description.sponsorshipAllenen_US
dc.description.sponsorshipGriceen_US
dc.description.sponsorshipAmmonsen_US
dc.description.sponsorshipAmerican Lung Associationen_US
dc.description.sponsorshipAmerican College of Surgeonsen_US
dc.description.sponsorshipVapotherm in industryen_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Center for Advancing Translational Sciences (NCATS)en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Center for Research Resources (NCRR) - KL2RR024151en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Heart Lung & Blood Institute (NHLBI) - K23HL087934en_US
dc.description.statementofresponsibilityWalkeren_US
dc.language.isoenen_US
dc.publisherAmerican Thoracic Societyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGeneral & internal medicineen_US
dc.subjectRespiratory systemen_US
dc.subjectRespiratory distress syndromeen_US
dc.subjectAdulten_US
dc.subjectPreventionen_US
dc.subjectPrediction modelen_US
dc.subjectAcute respiratory failureen_US
dc.subjectRespiratory-distress-syndromeen_US
dc.subjectCommunity-acquired pneumoniaen_US
dc.subjectIntensive-care-uniten_US
dc.subjectConsensus conferenceen_US
dc.subjectClinical predictorsen_US
dc.subjectVentilator settingsen_US
dc.subjectAcute-pancreatitisen_US
dc.subjectRelevant outcomesen_US
dc.subjectSeverity scoresen_US
dc.subjectValidationen_US
dc.subject.meshAcute lung injuryen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshArea under curveen_US
dc.subject.meshCohort studiesen_US
dc.subject.meshDisease progressionen_US
dc.subject.meshEarly diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPredictive value of testsen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshReproducibility of resultsen_US
dc.subject.meshRisk factorsen_US
dc.titleEarly identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort studyen_US
dc.typeArticleen_US
dc.identifier.wos000287568500010tr_TR
dc.identifier.scopus2-s2.0-78650060535tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-8111-5958tr_TR
dc.identifier.startpage462tr_TR
dc.identifier.endpage470tr_TR
dc.identifier.volume183tr_TR
dc.identifier.issue4tr_TR
dc.relation.journalAmerican Journal of Respiratory and Critical Care Medicineen_US
dc.contributor.buuauthorİşçimen, Remzi-
dc.contributor.researcheridAAI-8104-2021tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed20802164tr_TR
dc.subject.wosCritical care medicineen_US
dc.subject.wosRespiratory systemen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1en_US
dc.contributor.scopusid16645821200tr_TR
dc.subject.scopusAdult Respiratory Distress Syndrome; Acute Lung Injury; Artificial Ventilationen_US
dc.subject.emtreeAbdominal surgeryen_US
dc.subject.emtreeAcute lung injuryen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAdult respiratory distress syndromeen_US
dc.subject.emtreeArea under the curveen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAspirationen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeCohort analysisen_US
dc.subject.emtreeDeathen_US
dc.subject.emtreeDisease courseen_US
dc.subject.emtreeDisease predispositionen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFractureen_US
dc.subject.emtreeHeart surgeryen_US
dc.subject.emtreeHigh risk patienten_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLung contusionen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMulticenter studyen_US
dc.subject.emtreeNear drowningen_US
dc.subject.emtreeOutcome assessmenten_US
dc.subject.emtreePancreatitisen_US
dc.subject.emtreePatient identificationen_US
dc.subject.emtreePneumoniaen_US
dc.subject.emtreePredictionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSepsisen_US
dc.subject.emtreeShocken_US
dc.subject.emtreeSmokeen_US
dc.subject.emtreeSpine surgeryen_US
dc.subject.emtreeThorax surgeryen_US
dc.subject.emtreeTraumatic brain injuryen_US
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