1. Açık Erişim@BUU
  2. İndeksli Yayınlar
  3. Web of Science
Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29376
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dc.contributor.authorSudha, Thangirala-
dc.contributor.authorBharali, Dhruba J-
dc.contributor.authorDarwish, Noureldien H.E.-
dc.contributor.authorKeating, Kelly A-
dc.contributor.authorLin, Hung-Yun-
dc.contributor.authorDavis, Paul J.-
dc.contributor.authorMousa, Shaker A-
dc.date.accessioned2022-11-04T06:26:08Z-
dc.date.available2022-11-04T06:26:08Z-
dc.date.issued2017-02-
dc.identifier.citationSudha, T. vd. (2017). ''Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac''. Nanomedicine, 12(3), 195-205.en_US
dc.identifier.issn1743-5889-
dc.identifier.issn1748-6963-
dc.identifier.urihttps://doi.org/10.2217/nnm-2016-0315-
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/nnm-2016-0315-
dc.identifier.urihttp://hdl.handle.net/11452/29376-
dc.description.abstractAim: Nano-diamino-tetrac (NDAT) targets a receptor on integrin alpha v beta 3; alpha v beta 3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. The tetrac (tetraiodothyroacetic acid) of NDAT is covalently bound to a poly(lactic-co-glycolic acid) nanoparticle that encapsulates anticancer drugs. We report NDAT delivery efficiency of cisplatin to agent-susceptible urinary bladder cancer xenografts. Materials & methods: Cisplatin-loaded NDAT (NDAT-cisplatin) was administered to xenograft-bearing nude mice. Tumor size response and drug content were measured. Results: Intratumoral drug concentration was up to fivefold higher (p < 0.001) in NDAT-cisplatin-exposed lesions than with conventional systemic administration. Tumor volume reduction achieved was NDAT-cisplatin > NDAT without cisplatin > cisplatin alone. Conclusion: NDAT markedly enhances cisplatin delivery to urinary bladder cancer xenografts and increases drug efficacy.en_US
dc.description.sponsorshipNanoPharmaceuticals LLC (NY, USA)en_US
dc.description.sponsorshipNanoPharmaceuticals LLCen_US
dc.language.isoenen_US
dc.publisherFuture Medicineen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiotechnology & applied microbiologyen_US
dc.subjectScience & technology - other topicsen_US
dc.subjectCisplatinen_US
dc.subjectIntegrinen_US
dc.subjectNanotetracen_US
dc.subjectNDATen_US
dc.subjectTetraiodothyroacetic aciden_US
dc.subjectUrinary bladder carcinomaen_US
dc.subjectActivated protein-kinaseen_US
dc.subjectTetraiodothyroacetic aciden_US
dc.subjectThyroid-hormoneen_US
dc.subjectCancer-cellsen_US
dc.subjectPlatinumen_US
dc.subjectIntegrinen_US
dc.subjectReceptoren_US
dc.subjectGrowthen_US
dc.subjectDrugsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshCell culture techniquesen_US
dc.subject.meshCell lineen_US
dc.subject.meshTumoren_US
dc.subject.meshCell survivalen_US
dc.subject.meshCisplatinen_US
dc.subject.meshDrug delivery systemsen_US
dc.subject.meshDrug liberationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeterograftsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntegrin alphabeta3en_US
dc.subject.meshLactic aciden_US
dc.subject.meshMice, nudeen_US
dc.subject.meshNanoparticlesen_US
dc.subject.meshNeoplasm transplantationen_US
dc.subject.meshParticle sizeen_US
dc.subject.meshPolyglycolic aciden_US
dc.subject.meshSurface propertiesen_US
dc.subject.meshUrinary bladder neoplasmsen_US
dc.titleTargeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetracen_US
dc.typeArticleen_US
dc.identifier.wos000395674900006tr_TR
dc.identifier.scopus2-s2.0-85010383217tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.identifier.startpage195tr_TR
dc.identifier.endpage205tr_TR
dc.identifier.volume12tr_TR
dc.identifier.issue3tr_TR
dc.relation.journalNanomedicineen_US
dc.contributor.buuauthorYalçın, Murat-
dc.contributor.buuauthorCoşkun, Melis Debreli-
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.researcheridAAF-3992-2020tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed28102776tr_TR
dc.subject.wosBiotechnology & applied microbiologyen_US
dc.subject.wosNanoscience & nanotechnologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1 (Biotechnology & applied microbiology)en_US
dc.wos.quartileQ2 (Nanoscience & nanotechnology)en_US
dc.contributor.scopusid57192959734tr_TR
dc.contributor.scopusid57193066146tr_TR
dc.subject.scopusIntegrin; Thyroid Hormones; Nano-Diamino-Tetracen_US
dc.subject.emtreeAcetic acid derivativeen_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeNanocarrieren_US
dc.subject.emtreeNanodiaminotetracen_US
dc.subject.emtreeNanoparticleen_US
dc.subject.emtreePolyglactinen_US
dc.subject.emtreeTetraiodothyroacetic aciden_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeLactic aciden_US
dc.subject.emtreePolyglycolic aciden_US
dc.subject.emtreePolylactic acid-polyglycolic acid copolymeren_US
dc.subject.emtreeVitronectin receptoren_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBladder canceren_US
dc.subject.emtreeCancer sizeen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCovalent bonden_US
dc.subject.emtreeDrug delivery systemen_US
dc.subject.emtreeDrug dosage form comparisonen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeDrug responseen_US
dc.subject.emtreeDrug tissue levelen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeMouseen_US
dc.subject.emtreeNanoencapsulationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeTumor xenograften_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBladder tumoren_US
dc.subject.emtreeCancer transplantationen_US
dc.subject.emtreeCell culture techniqueen_US
dc.subject.emtreeCell survivalen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDrug delivery systemen_US
dc.subject.emtreeDrug releaseen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNude mouseen_US
dc.subject.emtreeParticle sizeen_US
dc.subject.emtreeSurface propertyen_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.emtreeXenograften_US
dc.subject.emtreeCisplatinen_US
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