Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29129
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dc.contributor.authorTortoriello, Drew V.-
dc.contributor.authorDayal, Molina-
dc.contributor.authorBeyhan, Zeki-
dc.date.accessioned2022-10-18T07:20:30Z-
dc.date.available2022-10-18T07:20:30Z-
dc.date.issued2016-06-30-
dc.identifier.citationTortoriello, D. V. vd. (2016). "Reanalysis of human blastocysts with different molecular genetic screening platforms reveals significant discordance in ploidy status". Journal of Assisted Reproduction and Genetics, 33(11), 1467-1471.en_US
dc.identifier.issn1058-0468-
dc.identifier.issn1573-7330-
dc.identifier.urihttps://doi.org/10.1007/s10815-016-0766-5-
dc.identifier.urihttps://link.springer.com/article/10.1007/s10815-016-0766-5-
dc.identifier.urihttp://hdl.handle.net/11452/29129-
dc.description.abstractThe objective of this study is to determine mosaicism and its effect on blastocysts; abnormal blastocysts determined by molecular testing were sequentially biopsied and retested. We re-biopsied 37 blastocyst-stage abnormal embryos from eight patients, which were reanalyzed to determine the level of concordance between biopsies and inter-laboratory congruence between reputable commercial PGS laboratories. The main outcome measures were intra-embryo variation between sequential embryo biopsies and inter-laboratory variation between two PGS laboratories. The compatibility between both aCGH and NGS was found to be 11 % (3/27). Importantly, 9/27 (33 %) of embryos originally reported to be aneuploid, upon repeat assessment, were found to be euploid. The concurrence for SNP array and NGS was 50 % (3/6), and 17 % (1/6) of these abnormal embryos tested normal upon re-evaluation with NGS. NGS resulted 41 % (11/27) normal results when 27 of CGH abnormal embryos were retested. Concordance between aCGH and NGS was 4 % (1/27) whereas in three instances, gender discrepancy was observed with NGS when aCGH abnormal embryos were reanalyzed. The results of these studies reinforce the prevalence of inconsistencies during PGS evaluation of trophectoderm biopsies possibly due to variations in platform sensitivity and heightening concerns over the clinical tractability of such technology in human ARTs..en_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGenetics & heredityen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectReproductive biologyen_US
dc.subjectPGSen_US
dc.subjectEmbryo biopsyen_US
dc.subjectMosaicismen_US
dc.subjectAneuploidyen_US
dc.subjectChromosome instabilityen_US
dc.subjectAneuploidyen_US
dc.subjectMosaicismen_US
dc.subjectDiagnosisen_US
dc.subjectTechnologyen_US
dc.subjectEmbryosen_US
dc.subject.meshAdulten_US
dc.subject.meshAneuploidyen_US
dc.subject.meshBiopsyen_US
dc.subject.meshBlastocysten_US
dc.subject.meshComparative genomic hybridizationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic testingen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMosaicismen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPreimplantation diagnosisen_US
dc.titleReanalysis of human blastocysts with different molecular genetic screening platforms reveals significant discordance in ploidy statusen_US
dc.typeArticleen_US
dc.identifier.wos000389192200008tr_TR
dc.identifier.scopus2-s2.0-84978920205tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi//Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0829-0992tr_TR
dc.identifier.startpage1467tr_TR
dc.identifier.endpage1471tr_TR
dc.identifier.volume33tr_TR
dc.identifier.issue11tr_TR
dc.relation.journalJournal of Assisted Reproduction and Geneticsen_US
dc.contributor.buuauthorYakut, Tahsin-
dc.contributor.buuauthorKeskintepe, Levent-
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed27423662tr_TR
dc.subject.wosGenetics & heredityen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.subject.wosReproductive biologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ3en_US
dc.wos.quartileQ2 (Obstetrics & gynecology)en_US
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid6602492477tr_TR
dc.subject.scopusPreimplantation Genetic Diagnosis; Aneuploidy; Blastocysten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBiopsy techniqueen_US
dc.subject.emtreeComparative genomic hybridizationen_US
dc.subject.emtreeEctodermen_US
dc.subject.emtreeEmbryoen_US
dc.subject.emtreeEmbryo biopsyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenetic screeningen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeBlastocysten_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMolecular geneticsen_US
dc.subject.emtreeMosaicismen_US
dc.subject.emtreeNext generation sequencingen_US
dc.subject.emtreeOutcome assessmenten_US
dc.subject.emtreePloidyen_US
dc.subject.emtreePrevalenceen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAneuploidyen_US
dc.subject.emtreeBiopsyen_US
dc.subject.emtreeBlastocysten_US
dc.subject.emtreeGenetic screeningen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMosaicismen_US
dc.subject.emtreePathologyen_US
dc.subject.emtreePregnancyen_US
dc.subject.emtreePreimplantation genetic diagnosisen_US
dc.subject.emtreeProceduresen_US
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