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http://hdl.handle.net/11452/29060
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aygün, Muhittin | - |
dc.date.accessioned | 2022-10-12T07:50:00Z | - |
dc.date.available | 2022-10-12T07:50:00Z | - |
dc.date.issued | 2016-05-24 | - |
dc.identifier.citation | Yılmaz, V. T. vd. (2016). "Ni(II)/Cu(II)/Zn(II) 5,5-diethylbarbiturate complexes with 1,10-phenanthroline and 2,2 '-dipyridylamine: synthesis, structures, DNA/BSA binding, nuclease activity, molecular docking, cellular uptake, cytotoxicity and the mode of cell death". Dalton Transactions, 45(25), 10466-10479. | en_US |
dc.identifier.issn | 1477-9226 | - |
dc.identifier.issn | 1477-9234 | - |
dc.identifier.uri | https://doi.org/10.1039/c6dt01726f | - |
dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2016/DT/C6DT01726F | - |
dc.identifier.uri | http://hdl.handle.net/11452/29060 | - |
dc.description.abstract | New 5,5-diethylbarbiturate (barb) complexes of Ni(II), Cu(II) and Zn(II) with 1,10-phenanthroline (phen) and 2,2'-dipyridylamine (dpya), namely [Ni(phen-kappa N,N')(3)]Cl(barb)center dot 7H(2)O (1), [Cu(barb-kappa N)(barb-kappa N-2,O)(phen-kappa N,N')]center dot H2O (2), [Cu(barb-kappa N)(2)(phen-kappa N,N')] (2a), [Zn(barb-kappa N)(2)(phen-kappa N,N')]center dot H2O (3), [Ni(barb-kappa N-2,O) (dpya-kappa N,N')(2)]Cl center dot 2H(2)O (4), [Cu(barb-kappa N-2,O)(2)(dpya-kappa N,N')]center dot 2H(2)O (5) and [Zn(barb-kappa N)(2)(dpya-kappa N,N')] (6), were synthesized and characterized by elemental analysis, UV-vis, FT-IR and ESI-MS. The structures of the complexes were determined by X-ray crystallography. Notably, 3 and 6 were fluorescent in MeOH : H2O at rt. The interaction of the complexes with fish sperm (FS) DNA and bovine serum albumin (BSA) was investigated in detail by various techniques. The complexes exhibited groove binding along with a partial intercalative interaction with DNA, while the hydrogen bonding and hydrophobic interactions played a major role in binding to BSA. It is noteworthy that 2 exhibited the highest affinity towards DNA and BSA. Enzyme inhibition assay showed that 1-4 show a preference for both A/T and G/C rich sequences in pUC19 DNA, while 5 and 6 display a binding specificity to the G/C and A/T rich regions, respectively. These findings were further supported by molecular docking. The cellular uptake studies suggested that 2 was deposited mostly in the membrane fraction of the cells. Among the present complexes, 2 exhibited a very strong cytotoxic effect on A549, MCF-7, HT-29 and DU-145 cancer cells, being more potent than cisplatin. Moreover, 2 induces cell death through the apoptotic mode obtained by flow cytometry. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Royal Soc Chemistry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Dna-binding | en_US |
dc.subject | Crystal-structures | en_US |
dc.subject | Copper(II) complexes | en_US |
dc.subject | Nickel(II) complexes | en_US |
dc.subject | Metal-complexes | en_US |
dc.subject | Donor ligands | en_US |
dc.subject | Anticancer | en_US |
dc.subject | Cleavage | en_US |
dc.subject | Drugs | en_US |
dc.subject | Adduct | en_US |
dc.subject | Bins | en_US |
dc.subject | Body fluids | en_US |
dc.subject | Cell death | en_US |
dc.subject | Cells | en_US |
dc.subject | Chlorine compounds | en_US |
dc.subject | Complexation | en_US |
dc.subject | Copper compounds | en_US |
dc.subject | Crystallography | en_US |
dc.subject | Cytology | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | DNA | en_US |
dc.subject | DNA sequences | en_US |
dc.subject | Enzyme inhibition | en_US |
dc.subject | Hydrogen bonds | en_US |
dc.subject | Hydrophobicity | en_US |
dc.subject | Molecular modeling | en_US |
dc.subject | Nickel | en_US |
dc.subject | Platinum compounds | en_US |
dc.subject | Synthesis (chemical) | en_US |
dc.subject | Zinc | en_US |
dc.subject | Zinc compounds | en_US |
dc.subject | 1 ,10-phenanthroline | en_US |
dc.subject | 5 ,5-diethylbarbiturate | en_US |
dc.subject | Binding specificities | en_US |
dc.subject | Bovine serum albumins | en_US |
dc.subject | Hydrophobic interactions | en_US |
dc.subject | Interaction with dnas | en_US |
dc.subject | Membrane fraction | en_US |
dc.subject | Molecular docking | en_US |
dc.subject | X ray crystallography | en_US |
dc.subject.mesh | 2,2'-Dipyridyl | en_US |
dc.subject.mesh | Antineoplastic agents | en_US |
dc.subject.mesh | Barbiturates | en_US |
dc.subject.mesh | Cell death | en_US |
dc.subject.mesh | Cell membrane | en_US |
dc.subject.mesh | Cisplatin | en_US |
dc.subject.mesh | Coordination complexes | en_US |
dc.subject.mesh | Copper | en_US |
dc.subject.mesh | Crystallography, x-ray | en_US |
dc.subject.mesh | DNA | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intercalating agents | en_US |
dc.subject.mesh | Molecular docking simulation | en_US |
dc.subject.mesh | Nickel | en_US |
dc.subject.mesh | Phenanthrolines | en_US |
dc.subject.mesh | Serum albumin, bovine | en_US |
dc.subject.mesh | Tumor cells, cultured | en_US |
dc.subject.mesh | Zinc | en_US |
dc.title | Ni(II)/Cu(II)/Zn(II) 5,5-diethylbarbiturate complexes with 1,10-phenanthroline and 2,2 '-dipyridylamine: synthesis, structures, DNA/BSA binding, nuclease activity, molecular docking, cellular uptake, cytotoxicity and the mode of cell death | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000378392200040 | tr_TR |
dc.identifier.scopus | 2-s2.0-84975885850 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı. | tr_TR |
dc.relation.bap | OUAP F-2014/17 | en_US |
dc.contributor.orcid | 0000-0002-2849-3332 | tr_TR |
dc.contributor.orcid | 0000-0003-3118-8061 | tr_TR |
dc.contributor.orcid | 0000-0002-2717-2430 | tr_TR |
dc.identifier.startpage | 10466 | tr_TR |
dc.identifier.endpage | 10479 | tr_TR |
dc.identifier.volume | 45 | tr_TR |
dc.identifier.issue | 25 | tr_TR |
dc.relation.journal | Dalton Transactions | en_US |
dc.contributor.buuauthor | Yılmaz, Veysel T. | - |
dc.contributor.buuauthor | Içsel, Ceyda | - |
dc.contributor.buuauthor | Suyunova, Feruza | - |
dc.contributor.buuauthor | Aztopal, Nazlıhan | - |
dc.contributor.buuauthor | Ulukaya, Engin | - |
dc.contributor.researcherid | L-7238-2018 | tr_TR |
dc.contributor.researcherid | AGZ-5109-2022 | tr_TR |
dc.contributor.researcherid | L-6687-2018 | tr_TR |
dc.contributor.researcherid | K-5792-2018 | tr_TR |
dc.contributor.researcherid | AAV-4886-2020 | tr_TR |
dc.contributor.researcherid | AAI-3342-2021 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.identifier.pubmed | 27263797 | tr_TR |
dc.subject.wos | Chemistry, inorganic & nuclear | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | PubMed | en_US |
dc.wos.quartile | Q1 | en_US |
dc.contributor.scopusid | 7006269202 | tr_TR |
dc.contributor.scopusid | 55551960400 | tr_TR |
dc.contributor.scopusid | 57189904966 | tr_TR |
dc.contributor.scopusid | 55853882900 | tr_TR |
dc.contributor.scopusid | 6602927353 | tr_TR |
dc.subject.scopus | Thiobarbituric Acid; Crystal Structure; DMV | en_US |
dc.subject.emtree | 1,10-phenanthroline | en_US |
dc.subject.emtree | 2,2' bipyridine | en_US |
dc.subject.emtree | 2,2'-dipyridylamine | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | Barbituric acid | en_US |
dc.subject.emtree | Barbituric acid derivative | en_US |
dc.subject.emtree | Bovine serum albumin | en_US |
dc.subject.emtree | Cisplatin | en_US |
dc.subject.emtree | Coordination compound | en_US |
dc.subject.emtree | Copper | en_US |
dc.subject.emtree | DNA | en_US |
dc.subject.emtree | Intercalating agent | en_US |
dc.subject.emtree | Nickel | en_US |
dc.subject.emtree | Phenanthroline derivative | en_US |
dc.subject.emtree | Zinc | en_US |
dc.subject.emtree | Analogs and derivatives | en_US |
dc.subject.emtree | Cell death | en_US |
dc.subject.emtree | Cell membrane | en_US |
dc.subject.emtree | Chemistry | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Molecular docking | en_US |
dc.subject.emtree | Synthesis | en_US |
dc.subject.emtree | Tumor cell culture | en_US |
dc.subject.emtree | X ray crystallography | en_US |
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