Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29039
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dc.contributor.authorPorszasz, Janos-
dc.contributor.authorCasaburi, Richard-
dc.contributor.authorStringer, William W.-
dc.contributor.authorBhatt, Surya P.-
dc.contributor.authorPak, Youngju-
dc.contributor.authorRossiter, Harry B.-
dc.contributor.authorWashko, George-
dc.contributor.authorCastaldi, Peter J.-
dc.contributor.authorEstepar, Raul San Jose-
dc.contributor.authorHansen, James E.-
dc.date.accessioned2022-10-11T05:54:05Z-
dc.date.available2022-10-11T05:54:05Z-
dc.date.issued2016-11-
dc.identifier.citationDilektaşlı, A. G. vd. (2016). "A novel spirometric measure identifies mild COPD unidentified by standard criteria". Chest, 150(5), 1080-1090.en_US
dc.identifier.issn0012-3692-
dc.identifier.issn1931-3543-
dc.identifier.urihttps://doi.org/10.1016/j.chest.2016.06.047-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0012369216526713-
dc.identifier.urihttp://hdl.handle.net/11452/29039-
dc.description.abstractBACKGROUND: In chronic obstructive pulmonary disease, both smaller and larger airways are affected. FEV1 mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. In this study, the objective was to evaluate the relationship between spirometric ratios, including the ratio of forced expiratory volume in 3 and 6 seconds (FEV3/FEV6), and small airways measures and gas trapping at quantitative chest CT scanning, and clinical outcomes in the Genetic Epidemiology of COPD (COPDGene) cohort. METHODS: Seven thousand eight hundred fifty-three current and ex-smokers were evaluated for airflow obstruction by using recently defined linear iteratively derived equations of Hansen et al to determine lower limit of normal (LLN) equations for prebronchodilator FEV1/FVC, FEV1/FEV6, FEV3/FEV6, and FEV3/FVC. General linear and ordinal regression models were applied to the relationship between prebronchodilator spirometric and radiologic and clinical data. RESULTS: Of the 10,311 participants included in the COPDGene phase I study, participants with incomplete quantitative CT scanning or relevant spirometric data were excluded, resulting in 7,853 participants in the present study. Of 4,386 participants with FEV1/FVC greater than or equal to the LLN, 15.4% had abnormal FEV3/FEV6. Compared with normal FEV3/FEV6 and FEV1/FVC, abnormal FEV3/FEV6 was associated with significantly greater gas trapping; St. George's Respiratory Questionnaire score; modified Medical Research Council dyspnea score; and BMI, airflow obstruction, dyspnea, and exercise index and with shorter 6-min walking distance (all P < .0001) but not with CT scanning evidence of emphysema. CONCLUSIONS: Current and ex-smokers with prebronchodilator FEV3/FEV6 less than the LLN as the sole abnormality identifies a distinct population with evidence of small airways disease in quantitative CT scanning, impaired indexes of physical function and quality of life otherwise deemed normal by using the current spirometric definition.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services - R01 HL 08 9856 - R01 HL 08 9897en_US
dc.description.sponsorshipNational Institutes of Health (NIH) - USA - 1KL2TR001419en_US
dc.description.sponsorshipNIH National Heart Lung & Blood Institute (NHLBI) - UL1TR001417 - KL2TR001419 - UL1TR001881en_US
dc.description.sponsorshipNIH National Center for Advancing Translational Sciences (NCATS) - U01HL089897 - U01HL089856 - R01HL124233 - R01HL089856 - R01HL089897en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGeneral & internal medicineen_US
dc.subjectRespiratory systemen_US
dc.subjectAirway obstructionen_US
dc.subjectCOPDen_US
dc.subjectSpirometryen_US
dc.subjectThoracic radiologyen_US
dc.subjectAir-flow obstructionen_US
dc.subjectComputed-tomographyen_US
dc.subjectReference valuesen_US
dc.subjectLung-functionen_US
dc.subjectSmall airwaysen_US
dc.subjectPulmonary-diseaseen_US
dc.subjectFEV1/FVC ratioen_US
dc.subjectFEV6en_US
dc.subjectEmphysemaen_US
dc.subjectFVCen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshDisability evaluationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPulmonary disease, chronic obstructiveen_US
dc.subject.meshQuality of lifeen_US
dc.subject.meshRisk assessmenten_US
dc.subject.meshRisk factorsen_US
dc.subject.meshSpirometryen_US
dc.subject.meshTomography, x-ray computeden_US
dc.titleA novel spirometric measure identifies mild COPD unidentified by standard criteriaen_US
dc.typeArticleen_US
dc.identifier.wos000387208600019tr_TR
dc.identifier.scopus2-s2.0-84994453368tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.identifier.startpage1080tr_TR
dc.identifier.endpage1090tr_TR
dc.identifier.volume150tr_TR
dc.identifier.issue5tr_TR
dc.relation.journalChesten_US
dc.contributor.buuauthorDilektaşlı, Aslı Görek-
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed27452770tr_TR
dc.subject.wosCritical care medicineen_US
dc.subject.wosRespiratory systemen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1en_US
dc.contributor.scopusid36466376600tr_TR
dc.subject.scopusSpirometry; Forced Expiratory Volume; Lung Functionen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAirway obstructionen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeCaucasianen_US
dc.subject.emtreeChronic obstructive lung diseaseen_US
dc.subject.emtreeClinical outcomeen_US
dc.subject.emtreeComputer assisted tomographyen_US
dc.subject.emtreeConference paperen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease associationen_US
dc.subject.emtreeDyspneaen_US
dc.subject.emtreeEmphysemaen_US
dc.subject.emtreeExerciseen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeForced expiratory volumeen_US
dc.subject.emtreeForced expiratory volume in six seconden_US
dc.subject.emtreeForced expiratory volume in three seconden_US
dc.subject.emtreeForced vital capacityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMedical research council dyspnea scoreen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRespiratory tract disease assessmenten_US
dc.subject.emtreeRespiratory tract parametersen_US
dc.subject.emtreeSix minute walk testen_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeSpirometryen_US
dc.subject.emtreeSt. George Respiratory Questionnaireen_US
dc.subject.emtreeThorax radiographyen_US
dc.subject.emtreeChronic obstructive lung diseaseen_US
dc.subject.emtreeClassificationen_US
dc.subject.emtreeDiagnostic imagingen_US
dc.subject.emtreeDisabilityen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeQuality of lifeen_US
dc.subject.emtreeRisk assessmenten_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeVery elderlyen_US
dc.subject.emtreeX-ray computed tomographyen_US
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