Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28293
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dc.date.accessioned2022-08-22T07:27:49Z-
dc.date.available2022-08-22T07:27:49Z-
dc.date.issued2007-07-06-
dc.identifier.citationKendall, M. (2007). "Fine airborne urban particles (PM2.5) sequester lung surfactant and amino acids from human lung lavage". American Journal Of Physiology-Lung Cellular and Molecular Physiology, 293(4), 1053-1058.en_US
dc.identifier.issn15221504-
dc.identifier.urihttps://doi.org/10.1152/ajplung.00131.2007-
dc.identifier.urihttps://journals.physiology.org/doi/full/10.1152/ajplung.00131.2007-
dc.identifier.urihttp://hdl.handle.net/11452/28293-
dc.description.abstractComponents of surfactant act as opsonins and enhance phagocytosis of bacteria; whether this process occurs with atmospheric fine particles has not been shown. We have studied the interactions of fine particles ( urban PM2.5) and surfactant removed from normal human lungs by lavage, using a surface analysis technique. The aim was to identify which of the chemical components of brochoalveolar lavage ( BAL) deposit on the surfaces of urban PM2.5. Deposition of surfactant components on urban PM2.5 surfaces was reported in previous studies, but molecular identification and relative quantification was not possible using simple data analysis. In this study, we were able to identify adsorbed components by applying an appropriate statistical technique, factor analysis. In this study, the most strongly associated mass fragment on PM2.5 surfaces exposed to BAL ( and undetected on both untreated samples and saline controls) was di-palmitoyl-phosphatidylcholine, a component of lung surfactant. Amino acids were also strongly associated with BAL-exposed PM2.5 surfaces and not other sample types. Thirteen mass fragments were identified, diagnostic of the amino acids alanine, arginine, asparagine, aspartic acid, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, serine, and valine. This study provides evidence that lung surfactant and amino acids related to opsonin proteins adsorb to nonbiological particle surfaces exposed to human lung lining fluid. Disruption of normal surfactant function, both physical and immunological, is possible but unproven. Further work on this PM-opsonin interaction is recommended.en_US
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBronchoalveolar lavageen_US
dc.subjectAdsorbed protein filmen_US
dc.subjectPhysiologyen_US
dc.subjectRespiratory systemsen_US
dc.subjectParticulate air-pollutionen_US
dc.subjectAdsorptionen_US
dc.subjectHealthen_US
dc.subjectSizeen_US
dc.subject.meshBronchoalveolar lavage fluiden_US
dc.subject.mesh1,2-Dipalmitoylphosphatidylcholineen_US
dc.subject.meshAdsorptionen_US
dc.subject.meshAmino acidsen_US
dc.subject.meshLungen_US
dc.subject.meshOpsonin proteinsen_US
dc.subject.meshFactor analysis, statisticalen_US
dc.subject.meshHumansen_US
dc.subject.meshParticle sizeen_US
dc.subject.meshParticulate matteren_US
dc.subject.meshPulmonary surfactantsen_US
dc.subject.meshUrban populationen_US
dc.titleFine airborne urban particles (PM2.5) sequester lung surfactant and amino acids from human lung lavageen_US
dc.typeArticleen_US
dc.identifier.wos000250054500024tr_TR
dc.identifier.scopus2-s2.0-35348897315tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Halk Sağlığı Anabilim Dalı.tr_TR
dc.identifier.startpage1053tr_TR
dc.identifier.endpage1058tr_TR
dc.identifier.volume293tr_TR
dc.identifier.issue4tr_TR
dc.relation.journalAmerican Journal Of Physiology-Lung Cellular and Molecular Physiologyen_US
dc.contributor.buuauthorKendall, Michaela-
dc.identifier.pubmed17616648tr_TR
dc.subject.wosPhysiologyen_US
dc.subject.wosRespiratory systemen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1en_US
dc.contributor.scopusid7201638493tr_TR
dc.subject.scopusPhotoelectron Spectroscopy; Aerosols; Sulfateen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeAirborne particleen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeFactorial analysisen_US
dc.subject.emtreeLung lavageen_US
dc.subject.emtreeLung surfactanten_US
dc.subject.emtreeParticulate matteren_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeQuantitative analysisen_US
dc.subject.emtreeUnited Kingdomen_US
dc.subject.emtreeGlutamineen_US
dc.subject.emtreeSurface propertyen_US
dc.subject.emtreeUrban areaen_US
dc.subject.emtreeGlutamic aciden_US
dc.subject.emtreeAlanineen_US
dc.subject.emtreeDipalmitoylphosphatidylcholineen_US
dc.subject.emtreeAmino aciden_US
dc.subject.emtreeGlycineen_US
dc.subject.emtreeAspartic aciden_US
dc.subject.emtreeArginineen_US
dc.subject.emtreeAsparagineen_US
dc.subject.emtreeHistidineen_US
dc.subject.emtreeIsoleucineen_US
dc.subject.emtreeLeucineen_US
dc.subject.emtreeLysineen_US
dc.subject.emtreeMethionineen_US
dc.subject.emtreeOpsoninen_US
dc.subject.emtreeSerineen_US
dc.subject.emtreeValineen_US
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