Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28256
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dc.contributor.authorAlkan, Samet-
dc.contributor.authorKayıran, Nuriye-
dc.contributor.authorZengin, Orhan-
dc.contributor.authorKalem, Ali-
dc.contributor.authorKimyon, Gezmiş-
dc.contributor.authorKılınç, Emine Özkul-
dc.contributor.authorKırtak, Necmettin-
dc.contributor.authorOnat, Ahmet Mesut-
dc.contributor.authorKısacık, Bünyamin-
dc.date.accessioned2022-08-18T12:25:48Z-
dc.date.available2022-08-18T12:25:48Z-
dc.date.issued2015-11-
dc.identifier.citationAlkan, S. vd. (2015). "Isotretinoin-induced spondyloarthropathy-related symptoms: A prospective study". Journal of Rheumatology, 42(11), 2106-2109.en_US
dc.identifier.issn0315-162X-
dc.identifier.issn1499-2752-
dc.identifier.urihttps://doi.org/10.3899/jrheum.150013-
dc.identifier.urihttps://www.jrheum.org/content/42/11/2106-
dc.identifier.urihttp://hdl.handle.net/11452/28256-
dc.description.abstractObjective. Acne vulgaris is a chronic inflammatory disease involving the pilosebaceous unit of the skin. Isotretinoin is a systemic retinoid that is often used as an effective treatment option for severe and treatment-resistant acne. Isotretinoin may also cause rheumatologic symptoms. The aim of this prospective observational study was to present followup results regarding the rheumatologic symptoms of patients who received systemic therapy for the treatment of acne (isotretinoin and tetracycline). Methods. For inclusion in the study, all consecutive patients with acne who were aged > 18 years were evaluated by the same dermatologist. The first 42 consecutive patients were included in the isotretinoin group, and after matching for age and sex, 32 consecutive patients were included in the tetracycline group. Isotretinoin treatment was planned as an average dose of 30 mg daily and a total dose of 120-150 mg/kg for 4-6 months. The patients were administered a dose of 1 g/day of tetracycline as 2 equal doses for 3 months. Results. Forty-two patients diagnosed with acne vulgaris were treated with isotretinoin 20.6 ± 4.4 (male/female: 17/22), and 32 patients were treated with tetracycline 20.6 ± 2.7 (male/female: 8/24). There was no significant difference between the 2 groups with respect to age and sex. Unilateral Achilles enthesopathy developed in 3 patients, whereas both Achilles enthesopathy and unilateral sacroiliitis developed in 1 patient. Inflammatory back pain developed in 6 patients in the isotretinoin group. Conclusion. To our knowledge, this was the first prospective observational study that assessed the rheumatologic symptoms of isotretinoin treatment. The spondyloarthropathy findings were identified in 23.1% of the patients who used isotretinoin.en_US
dc.language.isoenen_US
dc.publisherJournal of Rheumatology Publishing Companyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRheumatologyen_US
dc.subjectIsotretinoinen_US
dc.subjectSpondyloarthropathyen_US
dc.subjectEnthesitisen_US
dc.subjectInflammatory low back painen_US
dc.subjectAcne vulgarisen_US
dc.subjectAnkylosing-spondylitisen_US
dc.subjectSacroiliitisen_US
dc.subjectInflammatory back-painen_US
dc.subject.meshAcne vulgarisen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAge distributionen_US
dc.subject.meshCohort studiesen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshDrug administration scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIsotretinoinen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshRisk assessmenten_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshSex distributionen_US
dc.subject.meshSpondylarthropathiesen_US
dc.subject.meshTetracyclineen_US
dc.subject.meshYoung adulten_US
dc.titleIsotretinoin-induced spondyloarthropathy-related symptoms: A prospective studyen_US
dc.typeArticleen_US
dc.identifier.wos000365221400016tr_TR
dc.identifier.scopus2-s2.0-84946594102tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.tr_TR
dc.contributor.orcid0000-0002-1201-8836tr_TR
dc.identifier.startpage2106tr_TR
dc.identifier.endpage2109tr_TR
dc.identifier.volume42tr_TR
dc.identifier.issue11tr_TR
dc.relation.journalJournal of Rheumatologyen_US
dc.contributor.buuauthorPehlivan, Yavuz-
dc.contributor.researcheridAAG-8227-2021tr_TR
dc.relation.collaborationYurt içitr_TR
dc.identifier.pubmed26472411tr_TR
dc.subject.wosRheumatologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid13205593600tr_TR
dc.subject.scopusIsotretinoin; Acne Vulgaris; Retinoidsen_US
dc.subject.emtreeBilirubinen_US
dc.subject.emtreeErythromycinen_US
dc.subject.emtreeIsotretinoinen_US
dc.subject.emtreeNonsteroid antiinflammatory agenten_US
dc.subject.emtreeIsotretinoinen_US
dc.subject.emtreeTetracyclineen_US
dc.subject.emtreeAcne vulgarisen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBath ankylosing spondylitis disease activity indexen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug withdrawalen_US
dc.subject.emtreeEchographyen_US
dc.subject.emtreeEnthesopathyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFollow upen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInflammatory painen_US
dc.subject.emtreeLow back painen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNuclear magnetic resonance imagingen_US
dc.subject.emtreeObservational studyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeSacroiliitisen_US
dc.subject.emtreeSide effecten_US
dc.subject.emtreeSpondyloarthropathyen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAge distributionen_US
dc.subject.emtreeChemically induceden_US
dc.subject.emtreeCohort analysisen_US
dc.subject.emtreeComparative studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug administrationen_US
dc.subject.emtreeIncidenceen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreeRisk assessmenten_US
dc.subject.emtreeSeverity of illness indexen_US
dc.subject.emtreeSex ratioen_US
dc.subject.emtreeSpondylarthropathiesen_US
dc.subject.emtreeYoung adulten_US
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