Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/26427
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dc.contributor.authorSevimli, Alper-
dc.date.accessioned2022-05-12T12:22:08Z-
dc.date.available2022-05-12T12:22:08Z-
dc.date.issued2012-
dc.identifier.citationSevimli, A. vd. (2012). "Investigation of serum amino acid and serum amyloid A concentrations in chickens with amyloid arthropathy". Veterinary Quarterly, 32(1), 17-23.en_US
dc.identifier.issn0165-2176-
dc.identifier.issn1875-5941-
dc.identifier.urihttps://doi.org/10.1080/01652176.2012.689117-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01652176.2012.689117-
dc.identifier.urihttp://hdl.handle.net/11452/26427-
dc.description.abstractBackground: Increased proteolytic cleavage of serum amyloid A (SAA) may potentially contribute to the development of AA amyloid deposition Objective: To study the possible relationship between amyloid artropathy and expression of SAA and some serum amino acids. Animals and methods: Values of 15 serum amino acids and SAA were investigated in chickens with experimentally induced amyloid arthropathy. Thirty-four, 5-week-old chicks were allocated into two groups: one group was injected intra-articularly with 0.25mL complete Freund's adjuvant at the left tibio-metatarsal joint to induce amyloid arthropathy, whereas the other group served as control. All pullets were necropsied 13 weeks after injection. Collected tissue samples were examined histopathologically. Blood samples were collected and SAA concentrations were measured with enzyme-linked immunosorbent assay. High-performance liquid chromatography was used to assess the amino acid concentrations in serum. Results: Amyloid accumulation in joints occurred only in the experimental group (89%). SAA concentrations of 166 +/- 17 and 423 +/- 39 (SD) ng/mL were found in the control and experimental groups, respectively (p < 0.001). In the experimental group, an increase was observed in all examined amino acid concentrations except for citrulline. The most significant (p < 0.001) increases were noticed in serine (from 159 +/- 15 to 360 +/- 29 mu mol/L), glycine (from 151 +/- 20 to 279 +/- 16 mu mol/L), isoleucine (from 48 +/- 2 to 80 +/- 6 mu mol/L), and phenylalanine (from 49 +/- 2 to 90 +/- 3 mu mol/L). Conclusion: The results of this study suggest that there is a positive correlation between some serum amino acid values, especially serine, glycine, isoleucine, and phenylalanine, and the high concentrations of SAA in chickens with amyloid arthropathy.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectVeterinary sciencesen_US
dc.subjectAmyloiden_US
dc.subjectSaaen_US
dc.subjectArthropathyen_US
dc.subjectChickenen_US
dc.subjectAmino aciden_US
dc.subjectAcute phase proteinsen_US
dc.subjectA saaen_US
dc.subjectHaptoglobin hpen_US
dc.subjectVitamin-aen_US
dc.subjectExpressionen_US
dc.subjectDegradationen_US
dc.subjectArthritisen_US
dc.subjectVariablesen_US
dc.subjectDiseasesen_US
dc.subjectRabbiten_US
dc.subjectAnimaliaen_US
dc.subjectGallus gallusen_US
dc.titleInvestigation of serum amino acid and serum amyloid A concentrations in chickens with amyloid arthropathyen_US
dc.typeArticleen_US
dc.identifier.wos000304593000004tr_TR
dc.identifier.scopus2-s2.0-84930484938tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.relation.bap2001/42tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.orcid0000-0003-0537-2113tr_TR
dc.identifier.startpage17tr_TR
dc.identifier.endpage23tr_TR
dc.identifier.volume32tr_TR
dc.identifier.issue1tr_TR
dc.relation.journalVeterinary Quarterlyen_US
dc.contributor.buuauthorYalçın, Murat-
dc.contributor.buuauthorCangül, İ. Taci-
dc.contributor.buuauthorAydın, Sami-
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.researcheridAAB-4360-2021tr_TR
dc.relation.collaborationYurt içitr_TR
dc.identifier.pubmed22646841tr_TR
dc.subject.wosVeterinary sciencesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid57192959734tr_TR
dc.contributor.scopusid55237918600tr_TR
dc.contributor.scopusid7005387015tr_TR
dc.subject.scopusSerum Amyloid A Protein; Amyloidosis; Amyloid Enhancing Factoren_US
dc.subject.emtreeAmino aciden_US
dc.subject.emtreeGlycineen_US
dc.subject.emtreeIsoleucineen_US
dc.subject.emtreePhenylalanineen_US
dc.subject.emtreeSerineen_US
dc.subject.emtreeSerum amyloid aen_US
dc.subject.emtreeAmino acid analysisen_US
dc.subject.emtreeAmino acid blood levelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArthropathyen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood samplingen_US
dc.subject.emtreeConcentration (parameters)en_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeHigh performance liquid chromatographyen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeProtein expressionen_US
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