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Title: | Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs |
Authors: | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı. Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı. 0000-0001-9836-0749 İlçöl, Yeşim Özarda Yılmaz, Zeki Ulus, İsmail Hakkı AAL-8873-2021 D-5340-2015 A-9637-2008 35741320500 35944810500 7004271086 |
Keywords: | Neurosciences and neurology Free choline Phospholipid-bound choline Stress Glucocorticoid Dog Methylprednisolone Cortisol Acetylcholine Stress |
Issue Date: | 27-Mar-2003 |
Publisher: | Elsevier |
Citation: | İlçöl, Y. Ö. vd. (2003). “Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs”. Neuroscience Letters, 339(3), 195-198. |
Abstract: | We designed this study to determine whether serum free and phospholipid-bound choline concentrations change after surgery or methylprednisolone treatment in dogs and rats. In dogs, serum free and phospholipid-bound choline concentrations were decreased by 29% and 17% immediately after abdominal-pelvic surgery under xylasine + ketamine anesthesia, respectively, and both remained low for 24 h. Serum cortisol was elevated after surgery. The elevation in serum cortisol was inversely correlated with the decreases in free (r = -0.737; P < 0.001) and phospholipid-bound (r = -0.771; P < 0.001) choline concentrations. After methyprednisolone administration (5-20 mg/kg) free and phospholipid-bound choline concentrations decreased in a dose- and time-dependent manner. In rats, either surgery or methylprednisolone failed to alter serum free choline concentrations while phospholipid-bound choline decreased after surgery. These data show that the decrease in serum choline after surgery results from the increase in circulating glucocorticoids. |
URI: | https://doi.org/10.1016/S0304-3940(03)00035-1 https://www.sciencedirect.com/science/article/pii/S0304394003000351 http://hdl.handle.net/11452/26237 |
ISSN: | 0304-3940 |
Appears in Collections: | Scopus Web of Science |
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