Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/25962
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dc.contributor.authorAlp, Emine-
dc.contributor.authorKlaassen, Corne H.W.-
dc.contributor.authorDoğanay, Mehmet-
dc.contributor.authorAltoparlak, Ülkü-
dc.contributor.authorAydın, Kemalettin-
dc.contributor.authorEngin, Aynur-
dc.contributor.authorKuzucu, Çiğdem-
dc.contributor.authorÖzinel, Mehmet Ali-
dc.contributor.authorTurhan, Özge-
dc.contributor.authorVoss, Andreas-
dc.date.accessioned2022-04-21T11:56:49Z-
dc.date.available2022-04-21T11:56:49Z-
dc.date.issued2009-06-
dc.identifier.citationAlp, E. vd. (2009). "MRSA genotypes in Turkey: Persistence over 10 years of a single clone of ST239". Journal of Infection, 58(6), 433-438.en_US
dc.identifier.issn0163-4453-
dc.identifier.urihttps://doi.org/10.1016/j.jinf.2009.04.006-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0163445309001285-
dc.identifier.urihttp://hdl.handle.net/11452/25962-
dc.description.abstractObjectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of life-threatening human infections. The clinical impact of MRSA is mounting, not only due to the ever-increasing prevalence but also due to the occurrence of new, community-acquired MRSA strains. The aim of this prospective, multi-centre study was to determine the prevalence and genetic relatedness of clinically relevant MRSA isolates, in Turkey. Methods: During a 1-year period, data from 20 successive patients with invasive S. aureus infections were collected from eight university hospitals, geographically distributed over the six main regions of Turkey. Among these S. aureus isolates, the genetic association of MRSA isolates was investigated by pulsed-field get electrophoresis (PFGE) and spa typing. A selected number of isolates were also analyzed by multilocus sequence typing (MLST). Furthermore, Panton Valentine leucocidin (PVL) genes were examined. Results: In this study, the rate of methicillin resistance in S. aureus in patients with apparent infections (sepsis, meningitis, lung abscess or septic arthritis) ranged from 12 to 75% within the seven participating centres. Typing by pulsed-field get electrophoresis and spa typing revealed the presence of 22 closely related genotypes. According to the PFGE and spa typing results, 53 out of 54 MRSA isolates were closely related. These isolates were of spa type t030 or a related spa type, contain an SCC mec type III element and belong to sequence type ST239. None of the isolates contained the PVL genes. Conclusions: Despite the broad surface area of Turkey, a single predominant clone of ST239 circulates in hospitals in different regions and only few new types of MRSA were introduced over the past years. These results place Turkey in the epicenter of ST239 prevalence.en_US
dc.language.isoenen_US
dc.publisherW B Saundersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethicillin-resistanten_US
dc.subjectMolecular epidemiologyen_US
dc.subjectPanton Valentine leucocidin genesen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectResistant staphylococcus-aureusen_US
dc.subjectValentine leukocidin genesen_US
dc.subjectField gel-electrophoresisen_US
dc.subjectInfectionsen_US
dc.subjectStrainsen_US
dc.subjectPcren_US
dc.subjectEpidemiologyen_US
dc.subjectPneumoniaen_US
dc.subjectRegionen_US
dc.subjectInfectious diseasesen_US
dc.subject.meshAdolescenttr_TR
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBacterial proteinsen_US
dc.subject.meshBacterial toxinsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshCommunity-acquired infectionsen_US
dc.subject.meshCross infectionen_US
dc.subject.meshDisease susceptibilityen_US
dc.subject.meshElectrophoresis, gel, pulsed-fielden_US
dc.subject.meshExotoxinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshLeukocidinsen_US
dc.subject.meshMaleen_US
dc.subject.meshMethicillin-resistant staphylococcus aureusen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshStaphylococcal infectionsen_US
dc.subject.meshTurkeyen_US
dc.subject.meshYoung adulttr_TR
dc.titleMRSA genotypes in Turkey: Persistence over 10 years of a single clone of ST239en_US
dc.typeArticleen_US
dc.identifier.wos000267297400005tr_TR
dc.identifier.scopus2-s2.0-65649152538tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Klinik Mikrobiyoloji.tr_TR
dc.contributor.orcid0000-0001-5428-3630tr_TR
dc.identifier.startpage433tr_TR
dc.identifier.endpage438tr_TR
dc.identifier.volume58tr_TR
dc.identifier.issue6tr_TR
dc.relation.journalJournal of Infectionen_US
dc.contributor.buuauthorÖzakın, Cüneyt-
dc.contributor.researcheridAAG-8392-2021tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed19446883tr_TR
dc.subject.wosInfectious diseasesen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid57200678942tr_TR
dc.subject.scopusPanton-Valentine Leukocidin; Methicillin Resistant Staphylococcus Aureus; Staphylococcal Infectionsen_US
dc.subject.emtreeMeticillinen_US
dc.subject.emtreeOxacillinen_US
dc.subject.emtreePanton Valentine leukocidinen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAntibiotic resistanceen_US
dc.subject.emtreeAntibiotic sensitivityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBacterial arthritisen_US
dc.subject.emtreeBacterial geneticsen_US
dc.subject.emtreeBacterial meningitisen_US
dc.subject.emtreeBacterial strainen_US
dc.subject.emtreeBacterium identificationen_US
dc.subject.emtreeBacterium isolateen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeCloneen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenetic similarityen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeGeographic distributionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLung abscessen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMethicillin resistant Staphylococcus aureusen_US
dc.subject.emtreeMolecular epidemiologyen_US
dc.subject.emtreeMultilocus sequence typingen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreePulsed field gel electrophoresisen_US
dc.subject.emtreeSepsisen_US
dc.subject.emtreeStaphylococcus infectionen_US
dc.subject.emtreeTurkey (republic)en_US
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