Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22631
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dc.date.accessioned2021-11-12T08:33:01Z-
dc.date.available2021-11-12T08:33:01Z-
dc.date.issued2002-
dc.identifier.citationDilek, K. vd. (2002). "Long-term effects of losartan on proteinuria and renal function in patients with renal amyloidosis". Scandinavian Journal of Urology and Nephrology, 36(6), 443-446.en_US
dc.identifier.issn0036-5599-
dc.identifier.urihttps://doi.org/10.1080/003655902762467602-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/003655902762467602-
dc.identifier.urihttp://hdl.handle.net/11452/22631-
dc.description.abstractObjective: To investigate the effect of the angiotensin II receptor antagonist losartan oil proteinuria in secondary amyloidosis cases. Material and Methods: Sixteen patients with renal biopsy-proven AA amyloidosis with proteinuria were included in the study. All the patients had received colchicine treatment for at least 18 months. The patients were divided into two groups with similar age and gender distributions. Eight patients were given losartan at a dose of 50 mg/day for 12 months and the other 8 patients served as controls. Mean arterial blood pressure, proteinuria, serum albumin level and renal function were determined at the initiation of the study and after 1 and 12 months. Results: There were no significant differences in proteinuria, serum albumin level, renal function or mean arterial blood pressure at the initiation of the study. In the losartan group daily proteinuria decreased significantly from 5.2 +/- 0.7 at the initiation of the study to 3.9 +/- 1.2 g at 1 month and 3.6 +/- 0.8 g at 12 months, while in the control group it changed from 4.6 +/- 1.0 to 4.7 +/- 1.0 g and 6.1 +/- 1.2 g, respectively. The increment at 12 months was significant. After 12 months of treatment with losartan, proteinuria was significantly lower in comparison to the degree of proteinuria in the control group. Serum albumin level increased significantly in the losartan group but was unchanged in the control group. In the control group, creatinine clearance showed a significant decrease. There was no significant difference in mean arterial blood pressure measurements, serum creatinine levels, total protein, albumin and creatinine clearance levels between the two groups. Conclusions: Losartan seemed to prevent an increase in proteinuria without altering the creatinine clearance level in patients with amyloidosis type AA during a 12-month period. This indicates that losartan may be used to decrease proteinuria in this patient group. However, our results are only preliminary and need to be confirmed by larger studies.en_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiotensin II receptor blockadeen_US
dc.subjectLosartanen_US
dc.subjectProteinuriaen_US
dc.subjectRenal amyloidosis type AAen_US
dc.subjectTreatment resistanceen_US
dc.subjectRenin-angiotensin systemen_US
dc.subjectConverting-enzyme-inhibitionen_US
dc.subjectNephropathyen_US
dc.subjectRamiprilen_US
dc.subjectDiseaseen_US
dc.subjectTrialen_US
dc.subjectUrology & nephrologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAmyloidosisen_US
dc.subject.meshCreatinineen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKidneyen_US
dc.subject.meshKidney diseasesen_US
dc.subject.meshLosartanen_US
dc.subject.meshMaleen_US
dc.subject.meshProteinuriaen_US
dc.subject.meshReceptors, angiotensinen_US
dc.titleLong-term effects of losartan on proteinuria and renal function in patients with renal amyloidosisen_US
dc.typeArticleen_US
dc.identifier.wos000180716300007en_US
dc.identifier.scopus2-s2.0-0036973619en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-7528-3557tr_TR
dc.contributor.orcid0000-0002-0710-0923tr_TR
dc.identifier.startpage443tr_TR
dc.identifier.endpage446tr_TR
dc.identifier.volume36tr_TR
dc.identifier.issue6tr_TR
dc.relation.journalScandinavian Journal of Urology and Nephrologyen_US
dc.contributor.buuauthorDilek, Kamil-
dc.contributor.buuauthorUsta, Mehmet-
dc.contributor.buuauthorErsoy, Alparslan-
dc.contributor.buuauthorYavuz, Mahmut-
dc.contributor.buuauthorGüllülü, Mustafa-
dc.contributor.buuauthorYurtkuran, Mustafa Abbas-
dc.contributor.buuauthorÖzdemir, Binnaz Handan-
dc.contributor.researcheridX-8540-2019tr_TR
dc.contributor.researcheridAAH-5054-2021tr_TR
dc.identifier.pubmed12623509tr_TR
dc.subject.wosUrology & nephrologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ3en_US
dc.contributor.scopusid56005080200tr_TR
dc.contributor.scopusid7005030712tr_TR
dc.contributor.scopusid35612977100tr_TR
dc.contributor.scopusid7004168959tr_TR
dc.contributor.scopusid7006244754tr_TR
dc.contributor.scopusid6602684544tr_TR
dc.contributor.scopusid7003389525tr_TR
dc.subject.scopusRenin Angiotensin Aldosterone System; Angiotensin Receptor Antagonists; Diabetic Nephropathiesen_US
dc.subject.emtreeAlbuminen_US
dc.subject.emtreeAngiotensin receptor antagonisten_US
dc.subject.emtreeCalcium channel blocking agenten_US
dc.subject.emtreeColchicineen_US
dc.subject.emtreeCorticosteroiden_US
dc.subject.emtreeCreatinineen_US
dc.subject.emtreeDipeptidyl carboxypeptidase inhibitoren_US
dc.subject.emtreeDiuretic agenten_US
dc.subject.emtreeLosartanen_US
dc.subject.emtreeNonsteroid antiinflammatory agenten_US
dc.subject.emtreeSerum albumin adulten_US
dc.subject.emtreeProteinen_US
dc.subject.emtreeAge distributionen_US
dc.subject.emtreeAlbumin blood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClinical trialen_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCreatinine blood levelen_US
dc.subject.emtreeCreatinine clearanceen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeKidney amyloidosisen_US
dc.subject.emtreeKidney biopsyen_US
dc.subject.emtreeKidney functionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMean arterial pressureen_US
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