Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22187
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dc.date.accessioned2021-10-01T13:15:13Z-
dc.date.available2021-10-01T13:15:13Z-
dc.date.issued2006-
dc.identifier.citationYalçın, M. vd. (2006). ''The role of the central thromboxane A(2) in cardiovascular effects of a phospholipase A(2) activator melittin administrated intracerebroventricularly in normotensive conscious rats''. Neuropeptides, 40(3), 207-212.en_US
dc.identifier.issn0143-4179-
dc.identifier.issn1532-2785-
dc.identifier.urihttps://doi.org/10.1016/j.npep.2006.01.003-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0143417906000059-
dc.identifier.urihttp://hdl.handle.net/11452/22187-
dc.description.abstractThe current study was designed to determine the cardiovascular effect of centrally administrated melittin, a phospholipase A(2) (PLA(2)) activator, and the mediation of central thromboxane A(2) (TXA(2)) and its receptors in normotensive conscious rats. Studies were performed in normotensive male Sprague Dawley rats injected intracerebroventricularly (i.c.v.) with melittin. Melittin (1.5, 3.0, 6.0 mu g/5.0 mu l; i.c.v.) caused dose- and time-dependent increases in mean arterial pressure (MAP) and decrease in heart rate (HR). Maximal effects were observed 5-10 min after 3.0 mu g dose of melittin. In order to test the mediation of central TXA(2) and its central receptors in the cardiovascular effect of melittin, the rats were pretreated with furegrelate (500.0 mu g; i.c.v.), a TXA(2) synthesis inhibitor, and SQ-29548 (8.0 mu g; i.c.v.), a TXA(2) receptor antagonist, 15 min prior to melittin (3.0 mu g). Furegrelate or SQ-29548 partially inhibited the pressor effect and bradycardia elicited by melittin. In conclusion, our findings show that centrally administered melittin increases MAP and decreases HR in conscious rats. Moreover, according to our findings, central TXA(2) and its receptors may in part mediate melittin-induced cardiovascular effects.en_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectThromboxane A2en_US
dc.subjectMelittinen_US
dc.subjectMean arterial pressureen_US
dc.subjectIntracerebroventricularen_US
dc.subjectHeart rateen_US
dc.subjectBrain phospholipase A2en_US
dc.subjectAciden_US
dc.subjectAnalogen_US
dc.subjectReceptorsen_US
dc.subjectHemorrhageen_US
dc.subjectHypotensionen_US
dc.subjectInvolvementen_US
dc.subjectProstaglandinsen_US
dc.subjectSympatho-adrenomedullary outflowen_US
dc.subjectProstaglandinsen_US
dc.subjectAnimaliaen_US
dc.subject.meshThromboxane A2en_US
dc.subject.meshReceptors, thromboxane A2, prostaglandin H2en_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshRatsen_US
dc.subject.meshPhospholipases A2en_US
dc.subject.meshPhospholipases Aen_US
dc.subject.meshMelittenen_US
dc.subject.meshMaleen_US
dc.subject.meshHydrazinesen_US
dc.subject.meshHeart rateen_US
dc.subject.meshEnzyme inhibitorsen_US
dc.subject.meshEnzyme activationen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshBenzofuransen_US
dc.subject.meshAnimalsen_US
dc.titleThe role of the central thromboxane A(2) in cardiovascular effects of a phospholipase A(2) activator melittin administrated intracerebroventricularly in normotensive conscious ratsen_US
dc.typeArticleen_US
dc.identifier.wos000238162000006tr_TR
dc.identifier.scopus2-s2.0-33646413172tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.identifier.startpage207tr_TR
dc.identifier.endpage212tr_TR
dc.identifier.volume40tr_TR
dc.identifier.issue3tr_TR
dc.relation.journalNeuropeptidesen_US
dc.contributor.buuauthorYalçın, Murat-
dc.contributor.buuauthorAk, Füsün-
dc.contributor.buuauthorErtürk, Melih-
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.identifier.pubmed16524625tr_TR
dc.subject.wosNeurosciencesen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid57192959734tr_TR
dc.contributor.scopusid16038497200tr_TR
dc.contributor.scopusid13405914000tr_TR
dc.subject.scopusHistamine H4 Receptors; Thioperamide; Chlorpheniramine Maleateen_US
dc.subject.emtreeThromboxane A2 receptor blocking agenten_US
dc.subject.emtreeThromboxane A2 receptoren_US
dc.subject.emtreeThromboxane A2en_US
dc.subject.emtreePhospholipase A2en_US
dc.subject.emtreePartial agonisten_US
dc.subject.emtreeMelittinen_US
dc.subject.emtreeFuregrelateen_US
dc.subject.emtree7 [3 [(4 phenylsemicarbazido)methyl] 7 oxabicyclo[2.2.1]hept 2 yl] 5 heptenoic aciden_US
dc.subject.emtreeRaten_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreePressor responseen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeDrug receptor bindingen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeDose time effect relationen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCardiovascular effecten_US
dc.subject.emtreeBradycardiaen_US
dc.subject.emtreeBlood pressure regulationen_US
dc.subject.emtreeArticleen_US
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