Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/20962
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dc.date.accessioned2021-07-01T11:58:25Z-
dc.date.available2021-07-01T11:58:25Z-
dc.date.issued2001-
dc.identifier.citationAltan, L. vd. (2001). "Clinical investigation of methotrexate in the treatment of ankylosing spondylitis". Scandinavian Journal of Rheumatology, 30(5), 255-259.tr_TR
dc.identifier.issn0300-9742-
dc.identifier.urihttps://doi.org/10.1080/030097401753180318-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/030097401753180318-
dc.identifier.urihttp://hdl.handle.net/11452/20962-
dc.description.abstractObjectives: To investigate the efficacy and possible side effects of Methotrexate (MTX) treatment in patients with ankylosing spondylitis. Methods: A total of 51 patients with a diagnosis of AS according to NewYork criteria were randomly distributed into 2 groups. In Group I (n=25) only Naproxen (1000mg/day) and in Group II (n=26) oral MTX (7.5mg/week) combined with Naproxen were given for 12 months. The patients were evaluated at 3, 6, and 12 months after the start of the treatment according to a number of clinical parameters using objective and subjective variables. Data were analysed using ki-square and Mann-Whitney U tests. Results and conclusions: The comparison of the values using the percent changes and difference scores with respect to pretreatment values showed significant improvement in the "global evaluation of the physician" in Group II compared to Group I while no other parameter was found to be significantly different between the two groups. Those results have led us to conclude that a combination of MTX with Naproxen did not prove to be superior to Naproxen-alone treatment in terms of statistical significance. Further trials with MTX employing larger doses and different patient populations, mainly comprised of peripheral arthritis are necessary for delineation of the role of MTX in AS treatmenttr_TR
dc.language.isoentr_TR
dc.publisherTaylor & Francistr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectRheumatologytr_TR
dc.subjectSecond-line drugstr_TR
dc.subjectSpondylitistr_TR
dc.subjectMethotrexatetr_TR
dc.subjectRheumatoıd-arthritistr_TR
dc.subjectFunctional indextr_TR
dc.subjectLong-termtr_TR
dc.subjectSulfasalazinetr_TR
dc.subjectTherapytr_TR
dc.subjectPlacebotr_TR
dc.subjectTrialtr_TR
dc.titleClinical investigation of methotrexate in the treatment of ankylosing spondylitistr_TR
dc.typeArticletr_TR
dc.identifier.wos000171954000002tr_TR
dc.identifier.scopus2-s2.0-0034769918tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.identifier.startpage255tr_TR
dc.identifier.endpage259tr_TR
dc.identifier.volume30tr_TR
dc.identifier.issue5tr_TR
dc.relation.journalScandinavian Journal of Rheumatologytr_TR
dc.contributor.buuauthorAltan, Lale-
dc.contributor.buuauthorBingöl, Ümit-
dc.contributor.buuauthorKarakoç, Yüksel-
dc.contributor.buuauthorYurtkuran, Merih-
dc.contributor.buuauthorYurtkuran, Mustafa-
dc.contributor.buuauthorAydıner, Saadet-
dc.contributor.researcheridAAH-1652-2021tr_TR
dc.identifier.pubmed11727838tr_TR
dc.subject.wosRheumatologytr_TR
dc.indexed.wosSCIEtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.pubmedPubmedtr_TR
dc.wos.quartileQ2tr_TR
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